Changes of erythrocyte immunity function in rats with traumatic brain injury

Zhai Xuan; et al

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Changes of erythrocyte immunity function in rats with traumatic brain injury

更新时间：2024-01-17

- Changes of erythrocyte immunity function in rats with traumatic brain injury
- Journal of Chongqing Medical University Vol. 34, Issue 5, Pages: 529-532(2009)
- 作者机构：
  
  重庆医科大学附属儿童医院神经外科
- 作者简介：
- 基金信息：
- DOI：
  CLC： R651.15
- Published：2009，
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[1]翟瑄,梁平,夏佐中,李映良,周渝冬.脑创伤性鼠红细胞免疫功能的变化[J].重庆医科大学学报,2009,34(05):529-532.

Zhai Xuan, et al. Changes of erythrocyte immunity function in rats with traumatic brain injury. [J]. Journal of Chongqing Medical University 34(5):529-532(2009)
[1]翟瑄,梁平,夏佐中,李映良,周渝冬.脑创伤性鼠红细胞免疫功能的变化[J].重庆医科大学学报,2009,34(05):529-532. DOI：

Zhai Xuan, et al. Changes of erythrocyte immunity function in rats with traumatic brain injury. [J]. Journal of Chongqing Medical University 34(5):529-532(2009) DOI：

摘要

目的:探讨创伤性脑损伤（Traumatic brain injury

TBI）大鼠红细胞免疫功能（Erythrocyte immunity function

EIF）的改变及其机制。方法:选取Wistar大鼠70只

随机分成对照组（n=10）与创伤组（n=60）

创伤组制备成轻型（n=30）和中重型（n=30）创伤性脑损伤模型

酵母菌花环法检测对照组与创伤组大鼠血液中红细胞C3b受体花环率（RBC-C3bRR）和红细胞免疫复合物花环率（RBC-ICR）

放射免疫法测定血清中β-内啡肽（β-EP）水平。结果:与对照组比较

脑创伤大鼠RBC-C3bRR明显下降（P<0.05）

RBC-ICR和β-EP均明显升高（P<0.05）

中重型创伤组各指标改变较轻型创伤组更明显（P<0.05）。脑创伤大鼠β-EP变化与RBC-C3bRR呈直线负相关（轻型组r=-0.698

P<0.05;中重型组r=-0.744

P<0.05）;β-EP变化与RBC-ICR呈直线正相关（轻型组r=0.835

P<0.05;中重型组r=0.729

P<0.05）。结论:大鼠脑创伤后红细胞免疫功能明显下降

其改变与体内β-EP明显升高密切相关。

Abstract

Objective:Toexplore the changes and mechanismofErythrocyte ImmunityFunction(EIF)in rats with Traumatic Brain Injury(TBI).Methods:HealthyWistar rat(sn=70)were divided intocontrol group(n=10)and TBI group(n=60)

model ofTBI were prepared and divided into mild group(n=30)and moderate to severe group(n=30).Red Blood Cell-C3b Receptor Rate(RBC-C3bRR)and Red Blood Cell-Immune Complex Rate(RBC-ICR)of rats with TBI were measured by methed of yeast fungus and the content of serum β-endophin(β-EP)was tested by radioimmunoassay.Results:Compared with the control group

RBC-C3bRR of rats with TBI decreased significantly while RBC-ICR andβ-EP increased significantly(P<0.05).Moreover

the moderate to severe group had more manifest difference than the mild group(P<0.05).β-endorphin was negatively correlated with RBC-C3bRR(r=0.698

P<0.05)and positively with RBC-ICR(r=0.744

P<0.05)in mild group;and negatively correlated with RBC-C3bRR(r=-0.835

P<0.05)and positively with RBC-ICR(r=0.729

P<0.05)in moderate to severd group.Conclusion:EIF in rats with TBI decreased significantly which demonstrated erythrocyte immune dysfunction was related with increasing of theβ-EP.

关键词

创伤性脑损伤红细胞免疫β-内啡肽大鼠

Keywords

traumatic brain injuryErythrocyte immunityβ-endophinrats

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