UV determination of content of sustained-release dropping pills of oleanolic acid and its dissolution rate

LI Bi-bo; et al

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UV determination of content of sustained-release dropping pills of oleanolic acid and its dissolution rate

更新时间：2024-01-17

- UV determination of content of sustained-release dropping pills of oleanolic acid and its dissolution rate
- Journal of Chongqing Medical University Vol. 34, Issue 4, Pages: 447-451(2009)
- 作者机构：
  
  重庆医科大学药学院药物化学与生物材料研究室重庆高校药物工程研究中心
- 作者简介：
- 基金信息：
- DOI：
  CLC： R944.9
- Published：2009，
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[1]李必波,赵领,张雪梅,钟晓东,梁艳,余瑜.紫外光谱法测定齐墩果酸缓释滴丸药物含量及体外释放度[J].重庆医科大学学报,2009,34(04):447-451.

LI Bi-bo, et al. UV determination of content of sustained-release dropping pills of oleanolic acid and its dissolution rate. [J]. Journal of Chongqing Medical University 34(4):447-451(2009)
[1]李必波,赵领,张雪梅,钟晓东,梁艳,余瑜.紫外光谱法测定齐墩果酸缓释滴丸药物含量及体外释放度[J].重庆医科大学学报,2009,34(04):447-451. DOI：

LI Bi-bo, et al. UV determination of content of sustained-release dropping pills of oleanolic acid and its dissolution rate. [J]. Journal of Chongqing Medical University 34(4):447-451(2009) DOI：

摘要

目的:建立紫外光谱法测定齐墩果酸缓释滴丸药物含量及体外释放度。方法:采用尤尼柯UV-2102PCS型紫外可见分光光度计

在207nm波长处

测定齐墩果酸缓释滴丸的药物含量及体外释放度。结果:含量测定时

齐墩果酸在20～80μg/ml范围内

线性关系良好r=0.9995（n=7）

回收率在98%～102%之间

RSD<1%（n=3）;释放度测定时

齐墩果酸在10～70μg/ml范围内

线性关系良好r=0.9997（n=7）

回收率在98%～102%之间

RSD≤1%（n=3）。结论:该测定方法简便、快速

结果准确可靠、重现性好

可作为该制剂的质量控制方法。

Abstract

Objective:To establish UV method for the determination ofcontent of sustained-release droppingpills of oleanolic acid and its dissolution rate.Methods:In 207 nm wavelength

the content of sustained-release dropping pills of oleanolic acid and its dissolution rate were determinated by unico UV-2102PCS.Results:During the determination of the content

the calibration curves was linear in the concentration range of 20～80μg/ml

r=0.9995(n=7)

The recovery rate was 98.0%～102%

RSD<1%(n=3);during determining the dissolution rate

linearity was good within the concentration range of 10～70μg/ml

r=0.9997(n=7).The recovery rate was 98.0%～102%

RSD≤1%(n=3).Conclusion:The method is simple and rapid

and the results is accurate

reliable

and reproducible.It can be used to control the quality of sustained-release dropping pills of oleanolic acid with satisfactory results.

关键词

齐墩果酸缓释滴丸含量测定释放度

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Related Author

YAN Bo

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辜鹏程

尚京川

Related Institution

Department of Pharmaceutical Analysis,College of Pharmacy,Chongqing Medical University

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