Diagnostic value of multi-tumor marker protein biochip detective system for primary hepatic cancer

ZHANG Shu; et al

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Diagnostic value of multi-tumor marker protein biochip detective system for primary hepatic cancer

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- Diagnostic value of multi-tumor marker protein biochip detective system for primary hepatic cancer
- Journal of Chongqing Medical University Vol. 34, Issue 6, Pages: 760-762(2009)
- 作者机构：
  
  1. 湖南省人民医院核医学科
  2. 湖南省人民医院药剂科
- 作者简介：
- 基金信息：
- DOI：
  CLC： R735.7
- Published：2009，
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[1]张曙,张先瑞,殷跃.多肿瘤标志物蛋白芯片技术在原发性肝癌诊断中的评价[J].重庆医科大学学报,2009,34(06):760-762.

ZHANG Shu, et al. Diagnostic value of multi-tumor marker protein biochip detective system for primary hepatic cancer. [J]. Journal of Chongqing Medical University 34(6):760-762(2009)
[1]张曙,张先瑞,殷跃.多肿瘤标志物蛋白芯片技术在原发性肝癌诊断中的评价[J].重庆医科大学学报,2009,34(06):760-762. DOI：

ZHANG Shu, et al. Diagnostic value of multi-tumor marker protein biochip detective system for primary hepatic cancer. [J]. Journal of Chongqing Medical University 34(6):760-762(2009) DOI：

摘要

目的:探讨多肿瘤标记物蛋白芯片对原发性肝癌的诊断价值。方法:以病理检查或至少1年的临床随访结果为金标准

将2005～2007在我院就诊患者分为原发性肝癌组、良性肝病组和正常对照组

采用蛋白芯片测量技术检测其血清肿瘤标记物。结果:PHC组患者血清CA199、CEA、CA242、FER、AFP、CAl25和CA1537项显著高于健康对照组和良性肝病组（P<0.05）。Lo-gistic回归剔除FER

由其他6项指标诊断PHC的模型为:LogitP=1.357+0.851CA199+1.164CEA+2.573CA242+3.241AFP+2.647CAl25+2.846CA153。6项肿瘤标志物单独检测时

AFP的AUC最大（P<0.05）;而6项肿瘤标志物联合检测的AUC要大于各项肿瘤标志物单项检测结果（P<0.05）。结论:应用多肿瘤标志物蛋白芯片技术确定CA199、CEA、CA242、AFP、CAl25和CA1536项的联合检测是筛检原发性肝癌的优化组合

对原发性肝癌的早期诊断有较高临床应用价值。

Abstract

Objective:To explore the diagnostic value of multi-tumor marker protein biochip detective system for primary hepatic cancer.Methods:Using pathological examination

or at least one-year clinical follow-up results for the gold standard

we divided patients with liver disease into three two groups:primary liver cancer group

benign liver disease group and normal group

using protein chip technology to detect the measurement serum tumor markers.Results:CA199

CEA

CA242

FER

AFP

CAl25 and CA153 were significantly higher in PHC group than those in benign liver disease group and normal group(P<0.05).Logistic regression excluding FER

from the other six indicators for the diagnosis of PHC model:Logit P=1.357 +0.851 CA199 +1.164 CEA +2.573 CA242 +3.241 AFP +2.647 CAl25 +2.846 CA153.Six tumor markers detected separately

the AUC of AFP is the largest(P<0.05);Combined measure of six tumor markers has greater AUC than the single tumor marker test(P<0.05).Conclusion:Combined CA199

CEA

CA242

AFP

CAl25 and CA153 is the optimum combination for early diagnosis of primary liver cancer

it has a high clinical value.

关键词

原发性肝癌肿瘤标记物蛋白芯片联合诊断

Keywords

primary liver cancerTumor markersProtein chipCombined measure

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