The clinical analysis of 12 patients with thrombotic Microangiopathy

TANG Lin; et al

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The clinical analysis of 12 patients with thrombotic Microangiopathy

更新时间：2024-01-17

- The clinical analysis of 12 patients with thrombotic Microangiopathy
- Journal of Chongqing Medical University Vol. 34, Issue 1, Pages: 114-117(2009)
- 作者机构：
  
  重庆医科大学附属第二医院肾内科
- 作者简介：
- 基金信息：
- DOI：
  CLC： R654.3
- Published：2009，
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[1]唐琳,蔡莹,李瑞雪,张玲.血栓性微血管病12例临床分析[J].重庆医科大学学报,2009,34(01):114-117.

TANG Lin, et al. The clinical analysis of 12 patients with thrombotic Microangiopathy. [J]. Journal of Chongqing Medical University 34(1):114-117(2009)
[1]唐琳,蔡莹,李瑞雪,张玲.血栓性微血管病12例临床分析[J].重庆医科大学学报,2009,34(01):114-117. DOI：

TANG Lin, et al. The clinical analysis of 12 patients with thrombotic Microangiopathy. [J]. Journal of Chongqing Medical University 34(1):114-117(2009) DOI：

摘要

目的:了解血栓性微血管病（Thrombotic microangiopathy

TMA）的临床特征及治疗

以加深对该病的认识。方法:对我院2004年10月～2007年12月诊断的12例TMA患者的类型、临床表现、治疗及预后进行回顾性分析。结果:患者主要临床表现为贫血（12/12）

血小板计数减低（12/12）

血清乳酸脱氢酶升高（12/12）

肾脏损害（12/12）;发热（5/12）;精神或神经系统症状（7/12）。3例行血浆置换治疗。1例治愈

4例好转

7例死亡。结论:TMA的病因复杂、病情危重

死亡率高

预后差

应根据TMA的类型选择不同的治疗方案以提高疗效、减少死亡率。

Abstract

Objective:To study the clinical characteristics and treatment of thrombotic microangiopathy(TMA)

to improve recognition of TMA.Method:Types

clinical and laboratory characteristics

treatment and prognoses of 12 patients with thrombotic microangiopathy admitted to our hospital between October 2004 and December 2007 were analyzed retrospective1y.Result:The clinical manifestations were characterized by microangiopathic hemolytic anemia(12/12)

thrombocytopenia(12/12)

elevated serum LDH value(12/12)

and renal lesion(12/12)

fever(5/12)

and neurological abnormalities or mental disorders(7/12).3 patients were treated by plasma exchange therapy.1 patient fully recovered

4 patients took a turn for the better

and 7 patients died.Conclusion:TMA is a kind of severe acute syndrome with complicated pathenogenesis and high mortality.Management should depend on the type of TMA in order to improve curative efficacy and reduce mortality.

关键词

血栓性微血管病临床分析诊断

Keywords

thrombotic microangiopathyclinical studiesdiagnosis

references

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Related Institution

Department of Radiology，The First Affiliated Hospital of Chongqing Medical University

Teaching and Research Section of Pathology，College of Basic Medical Sciences，Chongqing Medical University

Department of Traditional Chinese Medicine，Children’s Hospital，Zhejiang University School of Medicine/ National Clinical Research Center for Child Health

Department of Pediatrics，The Affiliated Hospital of Nanjing University of Chinese Medicine，The First Clinical Medical College of Nanjing University of Chinese Medicine

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