Objective:To explore severe acute mushroom poisoning with myocardial damage and the prognosis of the patient. Method: The clinical data of 18 cases of severe acute mushroom poisning treated from 1998 to 2007 in my hospital were collected and analyed retrospectively

and the biochemical indicators were compared. Results:18 cases of severe acute mushroom poisoning not only presented the gastrointestinal tract

liver

kidney toxicity

but particularly prominent cardiac toxicity

mainly as increase of myocardial enzymes

electrocardiogram changes and malignant arrhythmia. Given conventional detoxication

myocardial protection

anti-arrhythmia

blood purification treatment and so on

the patients showed a significant decline in serum concentrations of CR

BUN

ALT

AST

LDH

CK

CK-MB

and HBDH. The differences between pre-treatment and post-treatment indicators in both groups were significant (P<0.05). 2 patients died of ventricular tachycardia in the whole group. Conclusion:Severe mushroom poisoning have significant cardiac toxicity and easily cause malignant arrhythmia

is the leading cause of death. Blood perfusion

blood dialysis and other combined treatment

are significantly effective and improve the prognosis of the patients.