Relation between the expression of RARα,RARβ and endometrial carcinoma

ZHOU Hong; et al

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Relation between the expression of RARα,RARβ and endometrial carcinoma

更新时间：2024-01-17

- Relation between the expression of RARα,RARβ and endometrial carcinoma
- Journal of Chongqing Medical University Issue 11, Pages: 1323-1326(2008)
- 作者机构：
  
  重庆医科大学附属第二医院妇产科
- 作者简介：
- 基金信息：
- DOI：
  CLC： R737.33
- Published：2008，
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[1]周虹,钟玲,常淑芳.维甲酸受体α、β在子宫内膜癌组织中的表达及意义[J].重庆医科大学学报,2008(11):1323-1326.

ZHOU Hong, et al. Relation between the expression of RARα,RARβ and endometrial carcinoma. [J]. Journal of Chongqing Medical University (11):1323-1326(2008)
[1]周虹,钟玲,常淑芳.维甲酸受体α、β在子宫内膜癌组织中的表达及意义[J].重庆医科大学学报,2008(11):1323-1326. DOI：

ZHOU Hong, et al. Relation between the expression of RARα,RARβ and endometrial carcinoma. [J]. Journal of Chongqing Medical University (11):1323-1326(2008) DOI：

摘要

目的:通过检测子宫内膜癌组织中维甲酸受体α（Retinoic acid receptor α

RARα）及维甲酸受体β（Retinoic acidreceptor β

RARβ）表达情况

探讨维甲酸受体在子宫内膜癌发生发展及预后中的作用。方法:收集手术标本的石蜡切片48例

用免疫组化技术检测子宫内膜癌中RARα、RARβ的表达

评估其与临床病理参数之间的关系。结果:（1）RARα及RARβ的阳性表达率分别为47.92%（23/48）、25%（12/48）

RARα的表达明显高于RARβ。（2）子宫内膜癌中RARα的表达随手术病理分期的增加及组织分化程度的降低而升高

表现出显著性差异（P<0.01

P<0.01）

但与子宫内膜癌组织学分类、肌层侵润深度无关（P>0.05）。（3）RARβ的表达随着子宫内膜腺癌组织分化程度的降低而减少（P<0.05）

但与手术病理分期、组织学类型、肌层侵润深度无关（P>0.05）。结论:子宫内膜癌中存在RARα、RARβ表达

RARα的高表达与子宫内膜癌的发展有关

RARβ的表达缺失及RARα的高表达预示子宫内膜癌的预后不良。

Abstract

Objective:To evaluate the role of the retinoic acid receptor α(RARα)

retinoic acid receptor β(RARβ) in the devel-opment and prognosis of the endometrial carcinoma by detecting the expression of these receptors. Methods:48 cases of paraffin-embedded tissues were selected

including 42 cases of adenocarcinoma and 6 cases of adeno-squamous carcinoma of endometrium. Immunohistochemistry was used to detect the level of RARα and RARβ. The relation between the expression of these receptors and the clinical pathological parameters was evaluated. Results:The positive expression ratios of the RARα and RARβ were 47.92%(23/48)and 25.00%(12/48)

respectively. The level of RARα was significantly higher than that of RARβ(P<0.05). The expression of RARα in the endometrial carcinoma increased with the increase of the pathological stage and the decrease of the pathological differentiation

and the differences were significan(tP<0.01). But the relation between the expression of these two receptors and the histological classifecation was not significant

as well as the relation with the invasive depth in the muscle(P>0.05). The level of the RARβ decreased with the increasing of the malignancy extent of the endome-trial adenocarcinoma(P<0.05)

but there was no relationship between the level of the RARβ and the pathological stage

the his- tological classification

the invasive depth in the muscle(P>0.05)respectively. Conclusion:There is close relation between the ex-pression of the RARα and the development of the endometrial carcinoma. The defect of the RARβ and the high expression of the RARα indicates a bad prognosis of the endometrial carcinoma. Detection of these two is benefited receptors together for us to estimate the prognosis of the carcinoma.

关键词

子宫内膜癌RARαRARβ

Keywords

endometrial carcinomaRARαRARβ

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Related Institution

Central Laboratory of Yongchuan Hospital Affiliated to Chongqing Medical University

Department of Obstetrics and Gynecology,The First Affiliated Hospital of Chongqing Medical University

Department of Obstetrics and Gynecology,Yongchuan Hospital Affiliated to Chongqing Medical University

Department of Obstetrics and Gynecology,Affiliated Hospital of Zunyi Medical University

Department of Obstetrics and Gynecology,The Second Affiliated Hospital of Zunyi Medical University

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