The relationship between androgen receptor,thrombospondin-1 and angiogenesis in nonmalignant and malignant prostate tissue

TAN Yi; et al

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The relationship between androgen receptor,thrombospondin-1 and angiogenesis in nonmalignant and malignant prostate tissue

更新时间：2024-01-17

- The relationship between androgen receptor,thrombospondin-1 and angiogenesis in nonmalignant and malignant prostate tissue
- Journal of Chongqing Medical University Vol. 34, Issue 5, Pages: 582-585(2009)
- 作者机构：
  
  重庆医科大学附属第一医院泌尿外科
- 作者简介：
- 基金信息：
- DOI：
  CLC： R737.25
- Published：2009，
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[1]谭毅,王明,王连渠.雄激素受体、凝血酶敏感蛋白-1与前列腺良、恶性疾病血管生成的关系[J].重庆医科大学学报,2009,34(05):582-585.

TAN Yi, et al. The relationship between androgen receptor,thrombospondin-1 and angiogenesis in nonmalignant and malignant prostate tissue. [J]. Journal of Chongqing Medical University 34(5):582-585(2009)
[1]谭毅,王明,王连渠.雄激素受体、凝血酶敏感蛋白-1与前列腺良、恶性疾病血管生成的关系[J].重庆医科大学学报,2009,34(05):582-585. DOI：

TAN Yi, et al. The relationship between androgen receptor,thrombospondin-1 and angiogenesis in nonmalignant and malignant prostate tissue. [J]. Journal of Chongqing Medical University 34(5):582-585(2009) DOI：

摘要

目的:探讨雄激素受体（Androgen receptor

AR）、凝血酶敏感蛋白-1（Thrombosopndin-1

TSP-1）在良性前列腺增生（Benign prostatic hyperplasia

BPH）、前列腺癌（Prostate cancer

Pca）中的表达及与血管生成的关系。方法:良性前列腺增生20例;前列腺癌60例

前列腺癌组中根据Gleason分级

Gleason评分<7为低评分组前列腺癌（35例）

Gleason评分≥7为高评分组前列腺癌（25例）;无骨转移者47例

有骨转移者13例。运用免疫组化二步法检测各组中AR、TSP-1的表达水平及微血管密度（Microvesel density

MVD）。结果:BPH组中AR、TSP-1的表达高于Pca组（P<0.01）

MVD值低于Pca组（P<0.01）;在Pca中低评分组AR、TSP-1的表达高于高评分组（P<0.01）

MVD值低于高评分组（P<0.01）;无骨转移组AR、TSP-1的表达高于骨转移组（P<0.01）

MVD值低于有远处转移组（P<0.01）。AR、TSP-1阳性组的MVD值分别小于阴性组的MVD值（P<0.01）。TSP-1与AR呈正相关（r=0.722

P<0.05）。结论:AR、TSP-1在前列腺癌中均为低表达

且与肿瘤的Gleason评分及有无骨转移密切相关。前列腺癌中AR突变使TSP-1减少

从而促进血管生成。

Abstract

Objective:Toinvestigate the expression of androgen recepto(rAR)and thrombospondin-1(TSP-1)in human benign prostatic hyperplasi(aBPH)and prostate cance(rPca)

and to explore the relationship between them and angiogenesis.Methods:Eighty specimens from BPH(20)and Pca(60)were included in the study.The Pca was divided into low Gleason score group(Gleason score<7)and high Gleason score group(Gleason score≥7)

and into non-bone metastasis group and bone metastasis group.The expression of AR

TSP-1 and microvesel density(MVD)were detected by immunohisto-chemistry(two-step method).Results:The positive rates of AR and TSP-1 in BPH group were significantly higher than those in Pca group;the MVD mounts in BPH group was significantly lower than that in Pca group.The positive rates of AR and TSP-1 in lower Gleason score group were significantly higher than those in higher Gleason score group

and the MVD mounts in lower Gleason score group was significantly lower than that in higher Gleason score group.The positive rates of AR and TSP-1 in non-bone metastasis group were significantly higher than those in bone metastasis group

and the MVD mounts in non-bone metastasis group was significantly lower than that in bone metastasis group.MVD mounts in AR positive and TSP-1 positive group were significantly lower than those in AR negative and TSP-1negative group(all P<0.01).There was positive correlation between the expression of AR and TSP-1(r=0.722

P<0.05).Conclusion:Low expressions of AR and TSP-1in Pca have close relations with tumor Gleason score and condition of bone metastasis.Mutation of AR might repress TSP-1

which might promote angiogenesis in prostate cancer.

关键词

前列腺肿瘤良性前列腺增生雄激素受体凝血酶敏感蛋白-1微血管密度

Keywords

Prostate tumorbenign prostatic hyperplasiaandrogen receptorThrombospondin-1Microvesel density

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