The use of ultrasound to synergize the effect of taxol against human ovarian cancer cells HO-8910PM

LIU Shuai; et al

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The use of ultrasound to synergize the effect of taxol against human ovarian cancer cells HO-8910PM

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- The use of ultrasound to synergize the effect of taxol against human ovarian cancer cells HO-8910PM
- Journal of Chongqing Medical University Vol. 33, Issue 12, Pages: 1437-1439(2008)
- 作者机构：
  
  重庆医科大学生物医学工程系医学超声工程研究所
- 作者简介：
- 基金信息：
- DOI：
  CLC： R737.31
- Published：2008，
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[1]刘帅,杨艳,于廷和.超声联合紫杉醇对卵巢癌细胞HO-8910PM的体外作用[J].重庆医科大学学报,2008,33(12):1437-1439.

LIU Shuai, et al. The use of ultrasound to synergize the effect of taxol against human ovarian cancer cells HO-8910PM. [J]. Journal of Chongqing Medical University 33(12):1437-1439(2008)
[1]刘帅,杨艳,于廷和.超声联合紫杉醇对卵巢癌细胞HO-8910PM的体外作用[J].重庆医科大学学报,2008,33(12):1437-1439. DOI：

LIU Shuai, et al. The use of ultrasound to synergize the effect of taxol against human ovarian cancer cells HO-8910PM. [J]. Journal of Chongqing Medical University 33(12):1437-1439(2008) DOI：

摘要

目的:观察超声（Ultrasound

US）联合紫杉醇（Taxol）对高转移性人卵巢癌细胞HO-8910PM的体外抑制作用。方法:筛选1个对细胞抑制率约10%的超声剂量。观察此剂量时超声辐照与药物联合应用（6μg/ml或18μg/ml）对肿瘤细胞的抑制率。结果:紫杉醇浓度为6μg/ml时Taxol、Taxol+US组细胞抑制率分别为12.4%和11.7%（P>0.05）

浓度为18μg/ml时抑制率分别为27.8%和42.0%（P<0.05）。结论:超声可增强紫杉醇对卵巢癌细胞的抑制效应

这种协同作用只有当药物浓度高于临界值时才存在。

Abstract

Objective:To determine whether ultrasound could enhance the cytotoxicity of taxol against human ovarian cancer cells HO-8910PM

a cell line with highly metastatic potential.Methods:Cell-killing attributed to ultrasound was determined by tetrazolium assay

and then an insonation level with a slight cytotoxicity was singled out for investigating the synergism.Such a level of sonication was co-used with taxol to deacti-vate cancer cells.Results:Inhibition rates in groups Taxol and Taxol+US

were12.4% vs11.7%(P>0.05)when taxol waswith a concentration of 6 μg/ml and were 27.8% vs 42.0%(P<0.05)when taxol was 18 μg/ml

respectively.Qualitative evalua-tion confirmed that there existed a synergism between taxol and ultrasound

while the content of taxol was 18 μg/ml.Conclu-sion:Ultrasound potentiated the cytotoxicity of taxol against ovarian cancer cells

and the synergism occurred only when the concentration of taxol was above the critical level.

关键词

卵巢癌超声紫杉醇协同效应

Keywords

ovarian cancerultrasoundTaxolSynergism

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