Objective:To evaluate the therapeutic effect of neoadjuvent chemotherapy for grade Ⅲ and Ⅳ carcinoma in the digestive tracts

Methods: A total of 30 cases of carcinoma in the digestive tracts were collected;including 9 cases in grade Ⅲa

13 cases in grade Ⅲb

and 8 cases in grade Ⅳ admitted to our hospital.Through gastroscope、enteroscope and CT investigation after admission

20 cases had been determined as advanced carcinoma in the digestive tracts before operation.Then the cases underwent chemotherapy twice

were rechecked by CT

and finally accepted operation treatment.The changes of the cancer volume

labelling micovessel index CD105 and the content of the inhibitory protein of apoptosis survivin from excisional tumor tissue were compared after operation. Results: 1.The change of tumorvolumebeforeandafterchemotherapyshowedstatisticalsignificance(P<0.05)

andtherewasstatisticalsignificance(P<0.05)ofdifference between intervenient chemotherapy group and systematic chemotherapy group.2.Neogenetic microvessel density showed statistical significance(P<0.05)ofdifference between esach twoofthree groups(P<0.05). 3.The content ofinhibitoryprotein ofapoptosis survivin showed statistical significance(P<0.05)of difference between chemotherapy group and control group

but there was no statistical significance (P>0.05)between intervenient chemotherapy group and systematical chemotherapy group. None died from operation. Conclusion: Surgical therapy after neoadjuvent chemotherapy for advanced cancer in the digestive tracts can improve the rate of exairesis and therapic effect.