Objective:To evaluate the efficacy and safety of itraconazole in the treatment of fungal infection in the patients with hematological malignancies.Method:53 patients with malignant hematologic diseases were divided into three groups:empirical treatment group

suspected fungal infection group and established group.Itraconazole was given in a dose of 200mg twice daily in the first and the second days

from the third day in a dose of 200mg once daily.Response was established as normalization of temperature in the patients receiving itraconazole

and disappearance of clinical signs in the patients with suspected or established infection.Result:The 31 patients were eligible for efficacy evaluation for empirical treatment

and 25 responded to itraconazole(80.65%);of 9 established patients

6 responded to itraconazole(66.67%);of 13 suspected infection patients

10 responded to itraconazole(76.92%).As to the side effects

there were no rigor and fever

but hepatotoxiciy were present in 5.66%

and no nephrotoxicity.Conclusion:Itraconazole is a highly effective drug with low side effects in treatment of fungal infections.But the hepatic and renal function tests must be carried out regularly when itraconazole infection is used.