The effects of early anti-inflammatory therapy on the expression of bdnf in adult rats after reperfusion in focal cerebral ischemia

ZHANG Xiao-dong; et al

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The effects of early anti-inflammatory therapy on the expression of bdnf in adult rats after reperfusion in focal cerebral ischemia

更新时间：2024-01-17

- The effects of early anti-inflammatory therapy on the expression of bdnf in adult rats after reperfusion in focal cerebral ischemia
- Journal of Chongqing Medical University Issue S1, Pages: 48-51(2008)
- 作者机构：
  
  重庆医科大学附属第一医院神经内科重庆市神经病学重点实验室
- 作者简介：
- 基金信息：
- DOI：
  CLC： R743.3
- Published：2008，
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[1]张小东,万东,杨琴,吕发金,牟君,赵立波,李亚军,谢鹏.早期抗炎治疗对脑缺血/再灌注大鼠BDNF表达的影响[J].重庆医科大学学报,2008(S1):48-51.

ZHANG Xiao-dong, et al. The effects of early anti-inflammatory therapy on the expression of bdnf in adult rats after reperfusion in focal cerebral ischemia. [J]. Journal of Chongqing Medical University (S1):48-51(2008)
[1]张小东,万东,杨琴,吕发金,牟君,赵立波,李亚军,谢鹏.早期抗炎治疗对脑缺血/再灌注大鼠BDNF表达的影响[J].重庆医科大学学报,2008(S1):48-51. DOI：

ZHANG Xiao-dong, et al. The effects of early anti-inflammatory therapy on the expression of bdnf in adult rats after reperfusion in focal cerebral ischemia. [J]. Journal of Chongqing Medical University (S1):48-51(2008) DOI：

摘要

目的:探讨脑缺血/再灌注损伤后早期抗炎治疗对脑源性神经营养因子（Brain-derived neurotrophic factor

BDNF）表达的影响。方法:雄性SD大鼠116只随机分成5组

即假手术组（SC组）、单纯缺血/再灌注组（I/R组）、缺血/再灌注秋水仙碱干预组（Col组）、缺血/再灌注秋水仙碱和环磷酰胺联合干预组（CC组）以及缺血/再灌注维生素C干预组（VitC组）。采用线栓法制备大鼠大脑中动脉缺血/再灌注（MCAO）模型。造模成功后6h开始用药

每天给药1次

连续10d。检测BDNF在海马及梗死灶周边的表达情况。结果:I/R组大鼠海马及梗死灶周边BDNF阳性细胞较SC组和CC组明显增加（P<0.05）;VitC组和Col组与I/R组比较

差异无统计学意义（P>0.05）。结论:脑缺血/再灌注诱导了海马及梗死灶周边BDNF表达增强

秋水仙碱与环磷酰胺早期联合抗炎治疗明显地抑制了这种诱导作用

而单独的VitC和秋水仙碱对BDNF表达则没有影响。

Abstract

Objective:To investigate the effects of early anti-inflammatory therapy on the expression of brain-derived neurotrophic factor(BDNF) in adult rats after reperfusion in focal cerebral ischemia. Methods:116 male adult SD rats of middle cerebral artery occlusion/reperfusion(MCAO) made by intraluminal thread approach were randomly divided into 5 groups: 1) sham operation control group(SC group)

2)ischemia/reperfusion(I/R group)

3) cyclophosphamide and colchicin group(CC group)

4) colchicin group(Col group)

5)ascorbic acid group(VitC group). Medication was applied after 6 hours of operation

later once per day and last ten days.Then we detected the information of the expression of BDNF in hippocampus and peripheral focal cerebral ischemia. Results:The differences of BDNF positive cells counting in hippocampus and peripheral focal cerebral ischemia were not significant between the I/R group

Col group and VitC group(P>0.05)

while compared with I/R group

the decrease of positive cells counting in the CC group was significance(P<0.05). Conclusion:Ischemia plus reperfusion can induced the expression of BDNF in hippocampus and peripheral focal cerebral ischemia;The anti-inflammatory therapy of combination of cyclophosphamide and colchicin notably inhibited the expression of BDNF. While VitC or colchicin had no effection on the expression of BDNF.

关键词

抗炎治疗脑源性神经营养因子缺血/再灌注

Keywords

Anti-inflammatory therapybrain-derived neurotrophic factorIschemia/reperfusion

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