A primary study for the effect of intraoperative regional arterial infusion chemotherapy on gastric cancer

XIA Shu-sen; et al

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A primary study for the effect of intraoperative regional arterial infusion chemotherapy on gastric cancer

更新时间：2024-01-17

- A primary study for the effect of intraoperative regional arterial infusion chemotherapy on gastric cancer
- Journal of Chongqing Medical University Vol. 34, Issue 3, Pages: 293-296(2009)
- 作者机构：
  
  1. 重庆医科大学附属第一医院普外科
  2. 川北医学院附属医院普外一科
- 作者简介：
- 基金信息：
- DOI：
  CLC： R735.2
- Published：2009，
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[1]夏术森,张才全,王崇树,杜江.胃癌术中区域动脉灌注化疗作用的初步研究[J].重庆医科大学学报,2009,34(03):293-296.

XIA Shu-sen, et al. A primary study for the effect of intraoperative regional arterial infusion chemotherapy on gastric cancer. [J]. Journal of Chongqing Medical University 34(3):293-296(2009)
[1]夏术森,张才全,王崇树,杜江.胃癌术中区域动脉灌注化疗作用的初步研究[J].重庆医科大学学报,2009,34(03):293-296. DOI：

XIA Shu-sen, et al. A primary study for the effect of intraoperative regional arterial infusion chemotherapy on gastric cancer. [J]. Journal of Chongqing Medical University 34(3):293-296(2009) DOI：

摘要

目的:探讨胃癌术中区域动脉灌注化疗（Region alarterial infusion chemotherapy

RAIC）的作用。方法:采用SP免疫组化法检测术中RAIC前后30例胃癌原发灶中VEGF及Ki-67的表达

并进行病理观察。结果:术中RAIC后

肿瘤组织Ki-67和血管内皮生长因子（Vasailar endothelial growth factor

VEGF）的表达较术前降低

且两者差异均有显著性（P<0.05）;光镜检查发现癌细胞出现轻度细胞核固缩、肿胀

细胞浆凝固

细胞间质轻度水肿

炎性细胞浸润

部分病例可见轻度血管炎表现。透射电镜发现癌细胞细胞核肿胀

核异染色质凝集

核周间隙扩大

胞质线粒体肿胀

内质网扩张

高尔基复合体扩张。结论:胃癌术中RAIC

可明显降低Ki-67与VEGF的表达

改变癌组织的组织病理学形态

对降低癌细胞活性、预防术中医源性转移和术后复发具有积极作用。

Abstract

Objective:To evaluate the effect and mechanism ofintraoperative regional arterial infusion chemotherapy(RAIC)on gastric cancer. Methods: The expressions of Ki-67 and VEGF

in 30 cases of gastric cancer

before and after the treatment of intraoperative RAIC

were shown by SP immunohistochemical staining. And pathological changes of tumor were detected. Results:After the intraoperative RAIC

the expressions of Ki-67 and VEGF were significantly lower than those before treatmen(tP<0.05).Light microscope examination revealed a mild change of karyopyknosis

nuclear swelling

coagulation of cytoplasm in cancer cells

mild hydropsia of intercellular substance

invasion of inflammatory cells and mild vasculitis in some cases. Transmission electron microscope found that nuclear swelling

nuclear heterochromatin agglutination

nuclear-week gap expansion

mitochondrial swelling

endoplasmic reticulum expansion

and Golgi complex expansion.Conclusion:The intraoperative RAIC for gastric cancer could obviously depress the expressions of Ki-67 and VEGF and cause the histo-pathological changes of cancer cells. Intra operative RAIC could significantly inhibit invasion activity of cancer cells and reduce iatrogenic metastasis and post operative recurrence rate.

关键词

胃癌区域化疗Ki-67血管内皮生长因子病理学

Keywords

GastriccancerRegionalChemotherapyKi-67Vascularendothelialgrowthfacto(rVEGF)pathology

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