Objective:To evaluate the efficacy and safety of microporous polysaccharide hemispheres(MPH)in control of homostasis on residual liver after hepatectomy. Methods: 60 patients undergoing hepatectomy were randomized to four groups standard group

test group Ⅰ

test group Ⅱ

and control group. Patients in standard group(15 patients)were treated with routine surgical technique to achieve homostasis.In test group Ⅰ(15 patients)the MPH combined with absorbable haemostat were used as hemostatic agents while only the MPH was used in test group Ⅱ(15 patients). The other 15 patients were given absorbable haemostat as control group. The hemostasia time

the amount of blood transfusion during operation and three days after operations were evaluated

the other factors (ALT

Alb

biliary

PT)were also evaluated. Results: In the standard group

hemostasia time was (2.98±1.05) min; the blood transfusion amount was (400±200) ml during operations and (400±200) ml three days after operations; the amount of drainage was (350±100) ml. In the test group Ⅰ

hemostasia time was (3.10±0.85) min; the blood transfusion amount was (200±0) ml during operations and (200±100) ml three days after operations; the amount of drainage was (200±100) ml. In the test group Ⅱ

hemostasia time was (3.20±1.52) min; the blood transfusion amount was (200±200) ml during operations and (200±0) ml three days after operations; the amount of drainage was (150±100) ml

and while in control group

the corresponding results were (5.22±1.82) min

(600±200) ml

(400±200) ml

(400±150) ml

respectively. Satisfactory bleeding control was achieved in 5 patients with routline surgical technique

there was no significant diffterence among them. The incidence of hemostasis in control group (33%)was significantly lower than that in standard group(80%) and all test groups(73.3%

66.7%

respectively). No hemostatic complications were noted in either group. Conclusion: MPH provides rapid

effective and safe hemostasis after hepatectomy

which can be applied in hepatectomy.