Objective:To establish neonatal γ-ray irradiated injury model of diffuse cortical dysplasias(DCD)in rats to observe the features of pathology

and discuss the mechamism of pathology and epileprogenesis in this model.Methods:γ-ray-induced model of DCD was established in rat.We observed the cerebral cortex change with naked eyes and under a light microscope

and assessed the hippocampal mossy fiber sprouting after HE staining

Nissl staining and Timm’s histochemical method.The comparisons between every two groups were performed with Nemenyi test.Results:The rats had seizure by chance

but most of these rats displayed more active action

exiting and so on.EEG showed frequent spontaneous sharp waves

or spikes from the frontal or the hippocampal neocortical structures.Neonatal γ-ray irradiated injury could result in DCDs in cerebral cortex and mossy fiber sprouting in hippocampi CA3 area bilaterally(nonparametric Kruskal-Wallis H test and Nemenyi test

P<0.05).Conclusion:Neonatal γ-ray irradiated injury could result in an ideal animal model simulating human cortical dysplasia

periventricular nodular heterotopia

and loss of lamination.