Clinical analysis of 103 cases of inpatients with fungal infections in the lungs

LI Wei-ming; et al

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Clinical analysis of 103 cases of inpatients with fungal infections in the lungs

更新时间：2024-01-17

- Clinical analysis of 103 cases of inpatients with fungal infections in the lungs
- Journal of Chongqing Medical University Vol. 34, Issue 8, Pages: 1112-1115(2009)
- 作者机构：
  
  1. 成都市第六人民医院呼吸内科
  2. 重庆医科大学附属第一医院老年病科
- 作者简介：
- 基金信息：
- DOI：
  CLC： R519
- Published：2009，
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[1]李伟铭,马厚勋.103例肺部真菌感染临床分析[J].重庆医科大学学报,2009,34(08):1112-1115.

LI Wei-ming, et al. Clinical analysis of 103 cases of inpatients with fungal infections in the lungs. [J]. Journal of Chongqing Medical University 34(8):1112-1115(2009)
[1]李伟铭,马厚勋.103例肺部真菌感染临床分析[J].重庆医科大学学报,2009,34(08):1112-1115. DOI：

LI Wei-ming, et al. Clinical analysis of 103 cases of inpatients with fungal infections in the lungs. [J]. Journal of Chongqing Medical University 34(8):1112-1115(2009) DOI：

摘要

目的:探讨肺部真菌感染发病的危险因素、临床特征、治疗和预后。方法:应用回顾性调查的方法对103例肺部真菌感染患者进行分析。结果:90%（90/103）的病例患有基础疾病

其中以慢性阻塞性肺疾病（Chronic obstractive pulmonary disease

COPD）和慢性肺源性心脏病为多见

其中有两种或两种以上基础疾病者68例

占66.02%。2型糖尿病也占有重要位置。肺部真菌感染的临床表现无特异性

X线表现以支气管肺炎多见（61%）。真菌培养结果显示病原菌主要以酵母菌属为主

包括白色念珠菌73株（70.8%）

热带念珠菌11株（10.7%）

光滑念珠菌10株（9.7%）

曲霉菌6株（5.8%）

毛霉菌3株（2.9%）;早期诊断仍困难。痰培养显示真菌与细菌复合感染常见（46.6%）

主要合并铜绿假单孢菌、不动杆菌、耐甲氧西林金黄色葡萄球菌、大肠杆菌感染。肺部真菌感染病死率较高

占21.36%

其中死于真菌感染未控制者6例

因抗真菌治疗延误并发多器官功能衰竭死亡16例。结论:肺部真菌感染是多种疾病继发感染的重要原因

其临床表现特异性少

病死率高

值得临床医生高度重视。

Abstract

Objective:To discover the risk factors

clinical features

treatment and prognosis of fungal infection in the lungs.Methods:The data of 103 patients suffering from fungal infection in the lungs were analyzed retrospectively.Results:There were ninety percent(91/103) of patients with underlying diseases

mainly chronic obstructive pulmonary disease(COPD) and chronic cor pulmonale.68(66.02%) patients suffered from two or more than two kinds of underlying diseases.Type 2 diabetes also took an important position in all underlying diseases.Clinical manifestations of pulmonary fungal infection showed no specificity.X-ray appearance showed that bronchopneumonitis was predominated(60%).The fungal culture results showed that blastocystis was the major pathogenic fungus

including 73(70.8%)strains of Candida albicans

11(10.7%) strains of Candida tropicalis

10(9.7%) strains of Torulopsis glabrata

6(5.8%) strains of aspergilli and 3(2.9%)trains of mold fungus

and early diagnosis of this disease remained difficult.The results of sputum cultuer showed that 48(46.6%) patients suffered from pumomary fungal infection combined with other bacterial infections

such as Pseudomonas aeruginosa

Acinetobacteria

Methicillin-resistant Staphylococcus aureus(MRSA)

Escherichia coli and so on.The mortality of pulmonary fungal infection in this group was high(21.36%).6 patients died from uncontrolled fungal infections in the lungs and other16 patients died from mutiple organ failure due to delayed antifungeal therapy.Conclusions:Pulmonary fungal infection with few specific clinical manifestations and high mortality was an important cause of secondary infections in the patients suffering from many kinds of diseases

which is worthy of more attention in clinic.

关键词

肺部真菌易患因素临床特征治疗

Keywords

Pulmonary fungal infectionRisk factorclinical featuretreatment

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Related Institution

Department of Traditional Chinese Medicine，Children’s Hospital，Zhejiang University School of Medicine/ National Clinical Research Center for Child Health

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