Serum level of Livin,VEGF and IL-18,IFN-γ in vascular dementia patients

TAN Jia-ze; et al

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Serum level of Livin,VEGF and IL-18,IFN-γ in vascular dementia patients

更新时间：2024-01-17

- Serum level of Livin,VEGF and IL-18,IFN-γ in vascular dementia patients
- Journal of Chongqing Medical University Vol. 34, Issue 9, Pages: 1246-1249(2009)
- 作者机构：
  
  重庆医科大学附属第一医院神经内科、重庆市神经病学重点实验室
- 作者简介：
- 基金信息：
- DOI：
  CLC： R749.13
- Published：2009，
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[1]谭家泽,蔡志友.血管性痴呆患者血清Livin、VEGF与IL-18、IFN-γ水平的临床研究[J].重庆医科大学学报,2009,34(09):1246-1249.

TAN Jia-ze, et al. Serum level of Livin,VEGF and IL-18,IFN-γ in vascular dementia patients. [J]. Journal of Chongqing Medical University 34(9):1246-1249(2009)
[1]谭家泽,蔡志友.血管性痴呆患者血清Livin、VEGF与IL-18、IFN-γ水平的临床研究[J].重庆医科大学学报,2009,34(09):1246-1249. DOI：

TAN Jia-ze, et al. Serum level of Livin,VEGF and IL-18,IFN-γ in vascular dementia patients. [J]. Journal of Chongqing Medical University 34(9):1246-1249(2009) DOI：

摘要

目的:通过检测血管性痴呆患者抗凋亡因子（Livin）、血管内皮生长因子（Vascular endothelial growth factor

VEGF）、白细胞介素-18（Interleukin-18

IL-18）和干扰素-γ（Interferon-γ

IFN-γ）的血清水平值

探讨Livin、VEGF、IL-18、IFN-γ在血管性痴呆中的发病机制和作用

研究IL-18、IFN-γ与血管性痴呆细胞凋亡和血管修复的关系。方法:实验分为2组:正常组（N组）与血管性痴呆组。采用酶联免疫吸附测定法（ELISA）检测血管性痴呆患者血清VEGF、Livin、IL-18、IFN-γ浓度值。结果:IL-18与IFN-γ在血管性痴呆患者中明显高于对照组（P<0.05）

差异有统计学意义。且患者血浆IL-18与IFN-γ呈显著正相关（P<0.05）;对照组IL-18与IFN-γ无显著相关性（P>0.05）。VEGF与Livin在血管性痴呆患者中明显低于对照组（P<0.05）。血管性痴呆组IL-18、IFN-γ与VEGF、Livin具有负相关性（P<0.05）。结论:IL-18、IFN-γ参与了血管性痴呆发生发展的炎性反应过程

炎症反应降低血管损伤修复作用可能是血管性痴呆发病机制之一。

Abstract

Objective:To investigate the changes of Livin

VEGF

interleukin(IL)-18 and interferon(IFN)-γ in the plasma of patients with vascular dementia

and to observe role of Livin

VEGF

IL-18 and IFN-γ in the pathogenesis of vascular dementia. Methods:Enzyme-linked immunosorbent assay(ELISA) was used to detect the concentration of Livin

VEGF

IL-18 and IFN-γ in the serum of patients with vascular dementia. Results:Serum level of Livin and VEGF in the patients with vascular dementia were significantly lower than the control group(P<0.001). Serum level of IL-18 and IFN-γ in the patients with vascular dementia were significantly higher than the control group(P<0.001). Serum level of IL-18 was significantly positively correlated with IFN-γ in the patients. Serum level of IL-18 and IFN-γ in the patients showed negative correlation with Livin and VEGF. Conclutions:The concentration of IL-18 and IFN-γ in patients with vascular dementia were significantly higher and associated with Livin and VEGF. This suggested that IL-18

IFN-γ may be both involved in the functional and structural integrity of vessel in the process of vascular dementia.

关键词

血管性痴呆白细胞介素-18干扰素-γlivin血管内皮生长因子

Keywords

vascular dementiainterleukin-18Interferon-γlivinvascular endothelial growth factor

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