The experimental study of bFGF-fibrin gule-amniotic membrane on corneal alkali burns

CAI Ming-ming; et al

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The experimental study of bFGF-fibrin gule-amniotic membrane on corneal alkali burns

更新时间：2024-01-17

- The experimental study of bFGF-fibrin gule-amniotic membrane on corneal alkali burns
- Journal of Chongqing Medical University Vol. 34, Issue 9, Pages: 1239-1241(2009)
- 作者机构：
  
  重庆医科大学附属第一医院眼科
- 作者简介：
- 基金信息：
- DOI：
  CLC： R779.1
- Published：2009，
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[1]蔡明铭,赵敏.bFGF胶联羊膜缓释药膜治疗角膜碱烧伤的实验研究[J].重庆医科大学学报,2009,34(09):1239-1241.

CAI Ming-ming, et al. The experimental study of bFGF-fibrin gule-amniotic membrane on corneal alkali burns. [J]. Journal of Chongqing Medical University 34(9):1239-1241(2009)
[1]蔡明铭,赵敏.bFGF胶联羊膜缓释药膜治疗角膜碱烧伤的实验研究[J].重庆医科大学学报,2009,34(09):1239-1241. DOI：

CAI Ming-ming, et al. The experimental study of bFGF-fibrin gule-amniotic membrane on corneal alkali burns. [J]. Journal of Chongqing Medical University 34(9):1239-1241(2009) DOI：

摘要

目的:观察一种羊膜药物缓释材料-bFGF胶联羊膜缓释药膜治疗兔角膜碱烧伤的效果

为其临床应用提供实验依据。方法:将含有bFGF的纤维蛋白胶与羊膜胶联

制成bFGF胶联羊膜缓释药膜。建立新西兰大白兔角膜碱烧伤模型

45只新西兰大白兔随机分为bFGF胶联药膜移植组（bFAM）、单层羊膜移植组（AM）、对照组（CG）

每组15只。术后观察临床治疗效果;并分别于术后第7、14、28d各组处死5只动物

取标本作组织病理学检查

用免疫组织化学方法半定量检测角膜中bFGF的表达。结果:术后bFAM组在炎症反应、组织修复及抑制新生血管方面都显著优于AM组。术后7dbFAM组bFGF表达显著高于AM组及对照组

其余各时间点差异无统计学意义。结论:bFGF胶联羊膜缓释药膜移植治疗兔角膜碱烧伤较单层羊膜具有更好的治疗效果。

Abstract

Objective:To study the effect of a new medical biomaterial—bfgf-fibrin glue-amniotic membrane(bFAM) for corneal alkali burn and provide experimental foundation for the clinical application in the future. Methods: We use fibrin glue compounded with bFGF and amniotic membrane to prepare the bFAM. 45 New Zealand rabbits were used to make corneal alkali burn models and divided into 3 groups:bFAM group、amniotic membrane group、comparison group

each group have 15 rabbits. After operation

we observe the linical curative effect. 7d、14d and 28d after operation

5 corneas were extracted for histopathological analysis. The expression of bFGF in corneas was measured by immunohistochemistry analysis. Results: After operation

bFAM group have better curative effect than amniotic membrane group in Inflammatory reaction、tissue repair and anti-CNV. The expression of bFGF in bFAM group is much higher than amniotic membrane group and comparison group in the day 7 afer operation

and in other time points the expression have not distinct difference in all groups. Conclusion: Compared with single layer amniotic membrane

bFAM shows better curative effect for corneal alkali burn.

关键词

缓释纤维蛋白胶羊膜碱性成纤维细胞生长因子（bFGF）碱烧伤

Keywords

Sustained releaseFibrin glueAmniotic membraneFibroblast growth factor basic(bFGF)Alkali burn

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