Expression of VEGF and BMP-2 in osteosarcoma tissue and its clinical significance

FU Neng-gao; et al

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Expression of VEGF and BMP-2 in osteosarcoma tissue and its clinical significance

更新时间：2024-01-17

- Expression of VEGF and BMP-2 in osteosarcoma tissue and its clinical significance
- Journal of Chongqing Medical University Vol. 34, Issue 8, Pages: 1042-1046(2009)
- 作者机构：
  
  1. 重庆医科大学附属第二医院骨科
  2. 四川省南充市川北医学院附属医院骨科
- 作者简介：
- 基金信息：
- DOI：
  CLC： R738.1
- Published：2009，
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[1]付能高,柯珍勇.VEGF和BMP-2在骨肉瘤组织中的表达及临床意义[J].重庆医科大学学报,2009,34(08):1042-1046.

FU Neng-gao, et al. Expression of VEGF and BMP-2 in osteosarcoma tissue and its clinical significance. [J]. Journal of Chongqing Medical University 34(8):1042-1046(2009)
[1]付能高,柯珍勇.VEGF和BMP-2在骨肉瘤组织中的表达及临床意义[J].重庆医科大学学报,2009,34(08):1042-1046. DOI：

FU Neng-gao, et al. Expression of VEGF and BMP-2 in osteosarcoma tissue and its clinical significance. [J]. Journal of Chongqing Medical University 34(8):1042-1046(2009) DOI：

摘要

目的:探索VEGF和BMP-2在骨肉瘤组织中的表达与骨肉瘤的诊断、转移复发及预后的关系。方法:应用免疫组织化学法（S-P法）检测41例骨肉瘤组织中VEGF、BMP-2及CD34的表达

计算微血管密度（MVD）

并综合分析所有病例资料。结果:41例骨肉瘤患者中

VEGF及BMP-2阳性表达率分别为68.2%（28/41）和61.0%（25/41）

与肿瘤大小、Price’s分级、Dahlin’s组织学分型等无关（P>0.05）。VEGF阳性组BMP-2阳性率及MVD（分别为75%和40.25±8.02）与阴性组BMP-2阳性率及MVD（分别为30.8%和15.54±5.87）相比

差异有显著意义（P<0.05）。复发或转移组VEGF及BMP-2的阳性率（分别为92.9%和85.7%）明显高于无复发或转移组的VEGF及BMP-2的阳性率（分别为55.6%和48.1%）

差异具有显著意义（P<0.05）。VEGF及BMP-2阳性组的5年存活率（分别为7.1%和4%）明显低于VEGF及BMP-2阴性组的5年存活率（分别为46.2%和43.8%）

差异有显著意义（P<0.05）。结论:VEGF、BMP-2在骨肉瘤组织中呈高表达

VEGF的表达与BMP-2的表达及MVD显著相关

检测VEGF、BMP-2的表达和MVD值可以作为判断骨肉瘤转移复发和预后的重要指标。

Abstract

Objective:To explore the expression of VEGF and BMP-2 in osteosarcoma tissue and its association with diagnosis

metastasis/recurrence and prognosis of osteosarcoma.Methods:Immunohistochemical staining(SP method)was used to detect the expression of VEGF

BMP-2 and CD34 in specimens from 41 cases of osteosarcoma.Microvessel density was calculated

and overall information of all the 41 cases were analyzed.Results:In 41 cases

the positive rates of VEGF and BMP-2 were 68.2%(28/41)and 61.0%(25/41)respectively.The expression of VEGF and BMP-2 were not significantly correlated to tumor’s size

Price’s grade and Dahlin’s difierentiation(P>0.05).The positive rate of BMP-2 and MVD(75% and 40.25±8.02)in VEGF positive patients were respectively much higher than those(30.8%and 15.54±5.87)in VEGF negative patients(P<0.05).The positive rates of VEGF and BMP-2(92.9%and 85.7%)in patients with metastasis / recurrence were respectively remarkably higher than those(55.6% and 48.1%)in patients without metastasis/recurrence(P<0.05).The five-year survival rate in patients with positive expression of VEGF and BMP-2(7.1%and 4%)were significantly lower than that(46.2%and 43.8%)in negative control group(P<0.05).Conclusion:High expression of VEGF and BMP-2 were found in osteosarcoma tissue.The expression of VEGF was closely correlated to the expression of BMP-2 and MVD.Detection of VEGF and BMP-2 expression and MVD may be useful for judging metastasis/recurrence and prognosis of osteosarcoma.

关键词

骨肉瘤VEGFBMP-2免疫组织化学

Keywords

osteosarcomaVEGFBMP-2immunohistochemistry

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