Objective:To evaluate the effects of niacin on HDL-C and cardiovascular events in patients with coronary heart disease(CHD).Methods:94 patients with CHD were randomly divided into two groups.44 patients in the control group were given the second prevention of CHD only.50 patients in the treatment group received treatment with niacin simultaneously.Results:The HDL-C level increased by 10.6% in treatment group and 7.4% in control group after 1 month(P>0.05).After 3 months

the HDL-C level increased by 31.7% in treatment group and 8.7% in control group(P<0.05).Three months later

the HDL-C in treatment group maintained the higher level continuously than in control group.The occurrence rate of cardiovascular events was 25%in control group and 8% in treatment group(P<0.05).Conclusions:The treatment of niacin significantly increases the level of HDL-C and reduces the risk of cardiovascular events in patients with CHD.