The regulation investigation of the interaction between TACE and TGF-α

YANG Huan; et al

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The regulation investigation of the interaction between TACE and TGF-α

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- The regulation investigation of the interaction between TACE and TGF-α
- Journal of Chongqing Medical University Vol. 34, Issue 11, Pages: 1466-1469(2009)
- 作者机构：
  
  1. 重庆医科大学公共卫生学院生殖生理教研室
  2. 川北医学院检验科
- 作者简介：
- 基金信息：
- DOI：
  CLC： R321
- Published：2009，
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[1]杨环,朱兴春,杨戎,张文文,刘帅.TACE-TGF-α相互作用参与胚泡着床的机制研究[J].重庆医科大学学报,2009,34(11):1466-1469.

YANG Huan, et al. The regulation investigation of the interaction between TACE and TGF-α. [J]. Journal of Chongqing Medical University 34(11):1466-1469(2009)
[1]杨环,朱兴春,杨戎,张文文,刘帅.TACE-TGF-α相互作用参与胚泡着床的机制研究[J].重庆医科大学学报,2009,34(11):1466-1469. DOI：

YANG Huan, et al. The regulation investigation of the interaction between TACE and TGF-α. [J]. Journal of Chongqing Medical University 34(11):1466-1469(2009) DOI：

摘要

目的:探讨胚泡着床过程中转化生长因子α（Transforming growth factor-α

TGF-α）对肿瘤坏死因子-α转化酶（Tumor necrosis factor-converting enzyme

TACE/ADAM17）的反馈调控机制。方法:用逆转录聚合酶链反应（Reverse transcription polymerase chain reaction

RT-PCR）和免疫组化的方法分别检测实验组（注射TGF-α抗体）和对照组（注射小鼠血清）后子宫内膜TACE mRNA和蛋白的表达。结果:对照组TACE mRNA和蛋白明显高于实验组。结论:在胚胎着床过程中

TGF-α能反馈调控TACE在子宫内膜的表达

TACE-TGF-α-EGFR途径可能是胚胎着床的调控机制之一。

Abstract

Objective:To investigate the feedback regulation of transforming growth factor α(TGF-α)to tumor necrosis factor-α converting enzyme.Methods:Reverse transcription polymerase chain reaction(RT-PCR)and immunochemistry were applied to detect TACE mRNA and protein in mice endometria of experiment group(TGF-α antibody was injected)and control group(saline was injected).Results:The expressions of TACE mRNA and protein in control group were higher than in experiment group.Conclusion: TGF-α could feedback on TACE expression in mice endometria and TACE-TGF-α-EGFR might one of the regulations during blastocyst implantation.

关键词

胚胎着床肿瘤坏死因子-α转化酶转化生长因子α子宫内膜免疫组化逆转录聚合酶链反应

Keywords

Blastocyst implantationTumor necrosis factor alpha converting enzyme(TACE)Transforming growth factor-α(TGF-α)EndometriaImmunochemistryRT-PCR

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Related Institution

Department of Urology, College of Clinical Medicine, Chongqing Medical University

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Labortory of Reproductive Biology, Chongqing Medical University

重庆市渝中区人口和计划生育生殖健康中心

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