Objective:To evaluate the therapeutic effect of shuxuetong injection on diabetic peripheral neuropathy (DNP). Methods: Odds ratio of symptom improving between the treatment and control group was analyzed. Related published literatures on effect of shuxuetong on DPN were fully searched and screened through computed database. The data were extracted for summarizing all the studies

calculating the pooled OR and its 95% confidence interval(95% CI)

and testing the overall effects by RevMan 4.3.1. Both publication bias analysis and sensitivity analysis were performed for evaluating the reliability and stability of the meta-analysis. Other indexes in the literatures which were not adapted for meta-analysis were also described.Results:Eleven literatures

totally 937 cases

were obtained. Some heterogeneity were discovered between the studies (P=0.09). Shuxuetong injection may significantly relieve the symptom of patients with diabetic peripheral neuropathy. Its OR and 95%CI was 6.05 (3.83

9.55)(P<0.000 01). The results of sensitivity analysis and publication bias analysis accounted for the reliability and stability of this meta-analysis. Shuxuetong injection also played an role in raising nerve conduction velocity and reducing blood viscosity according to the results of the literatures.Conclusion:Shuxuetong injection can effectively relieve DPN symptoms

improve the relative laboratory indexes were also improved. It is a better method for DPN treatment.