Efficacy of thyroid hormone treatment and the serum levels of thyroid hormone in patients with primary nephritic syndrome

WANG Ya-jun; et al

您当前的位置：

首页 >

文章列表页 >

Efficacy of thyroid hormone treatment and the serum levels of thyroid hormone in patients with primary nephritic syndrome

更新时间：2024-01-17

- Efficacy of thyroid hormone treatment and the serum levels of thyroid hormone in patients with primary nephritic syndrome
- Journal of Chongqing Medical University Vol. 34, Issue 9, Pages: 1263-1265(2009)
- 作者机构：
  
  1. 都江堰市人民医院儿科
  2. 四川省成都市妇幼保健院新生儿科
- 作者简介：
- 基金信息：
- DOI：
  CLC： R726.9
- Published：2009，
扫描看全文
[1]王亚均,叶正蔚.慢性肾脏病患儿小剂量甲状腺素治疗的作用及甲状腺激素水平变化的意义[J].重庆医科大学学报,2009,34(09):1263-1265.

WANG Ya-jun, et al. Efficacy of thyroid hormone treatment and the serum levels of thyroid hormone in patients with primary nephritic syndrome. [J]. Journal of Chongqing Medical University 34(9):1263-1265(2009)
[1]王亚均,叶正蔚.慢性肾脏病患儿小剂量甲状腺素治疗的作用及甲状腺激素水平变化的意义[J].重庆医科大学学报,2009,34(09):1263-1265. DOI：

WANG Ya-jun, et al. Efficacy of thyroid hormone treatment and the serum levels of thyroid hormone in patients with primary nephritic syndrome. [J]. Journal of Chongqing Medical University 34(9):1263-1265(2009) DOI：

摘要

目的:探讨慢性肾脏病小剂量甲状腺素治疗的作用和甲状腺激素水平变化的意义。方法:患儿92例慢性肾脏病患儿随机分为甲状腺素治疗组和对照组

各46例

均予常规治疗。治疗组加服左旋甲状腺素组25～50μg/d。随访至少1月

比较2组的临床疗效

放射免疫分析法检测甲状腺素的水平。结果:治疗后1、2、4周

两组尿蛋白、尿潜血定性、Hb值及白蛋白水平无明显变化。但2组SCr与BUN在治疗后1周即均下降

并持续至第4周（P<0.05）

而治疗组下降更为明显（P<0.05）。甲状腺功能检测显示治疗组1周后FT3、FT4上升

TSH下降

并持续至第4周（P<0.05）

与对照组比水平也均有改善（P<0.05）。所有患者FT3与SCr浓度之间呈负相关

r值为-0.71（t=6.147

P=0.012）。结论:小剂量甲状腺素对小儿慢性肾脏病有治疗作用

其甲状腺素水平可以作为疗效检测和预后评价的一种指标。

Abstract

Objective:To investigate the efficacy of low-dose thyroid hormone treatment and the change in levels of thyroid hormone in patients with chronic kidney disease. Methods: 92 children with chronic kidney disease were randomly divided into thyroxine treatment group and control group

with 46 children in each group. All patients received conventional treatment

the treatment group served with additional Levothyroxine of 25 ~ 50μg/d. At least 1 month follow-up was taken to compare the clinical efficacy

RIA detection level of thyroxine. Results: In control group

urinary protein

urine occult blood

Hb and albumin showed no changes at 1w-4w after therapy

and the treatment group also showed this trend. There were no difference between two groups. However

1 week after treatment

SCr and BUN began to decline

till 4th week(P <0.05). Thyroxine and the treatment group and control group over the same period compared to 1 week after treatment and after the decline in SCr and BUN more obvious and continuing to 4 weeks(P <0.05). To thyroid function enhanced in patients in the treatment group at 1 week after treatment (P<0.05)

this trend is maintained up to 4 weeks after treatment;and 1 week after treatment

thyroid function in the treatment group with the same period was improved compared to the control group(P <0.05). FT3 and SCr for all patients showed a negative correlation between the concentration. The correlation coefficient was -0.71 (t = 6.147

P = 0.012). Conclusion: Small dose of thyroid hormone treatment have a good role in the treatment for children with chronic kidney disease. The efficacy of thyroid hormone levels can be used as an indicator for therapy and evaluation for prognosis.

关键词

慢性肾脏病甲状腺素治疗学儿童

Keywords

chronic kidney diseaseHormoneTherapychildren

references

Views

下载量

CSCD

Alert me when the article has been cited

提交

Tools

Publicity Resources

Epidemiological and clinical characteristics of human rhinovirus infection in children hospitalized due to lower respiratory tract infections in Yinchuan，China

Genetic testing of children with suspected thalassemia in Chongqing area of China: an analysis of 28 287 cases

Advances in clinical management of thyroid cancer in children and adolescents

Cluster analysis on types of family management for children with malignant tumor

Comparison of the application of rigid bronchoscope and soft bronchoscope in children's bronchial foreign bodies

Related Author

Hei Zhiping

Guo Jianhui

Ji Kai

Yan Yan

Wang Chunli

Li Fang

Sun Yuning

Wang Ming

Related Institution

Department of Biochemistry and Molecular Biology,School of Basic Medicine,Ningxia Medical University

Department of Clinical Medicine,Ningxia Medical University

Department of Respiratory and Critical Care Medicine,General Hospital of Ningxia Medical University

Department of Clinical Molecular Medicine of Children’s Hospital of Chongqing Medical University， National Clinical Research Center for Child Health and Disorders，Ministry of Education Key Laboratory of Child Development and Disorders，Chongqing Key Laboratory of Pediatrics

Department of Endocrinology， Guangdong Provincial People’s Hospital，Guangdong Academy of Medical;Sciences

⁰