Malignant renal angiomyolipoma a case report and literature review

YANG Chun-rong; et al

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Malignant renal angiomyolipoma a case report and literature review

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- Malignant renal angiomyolipoma a case report and literature review
- Journal of Chongqing Medical University Vol. 34, Issue 12, Pages: 1767-1770(2009)
- 作者机构：
  
  重庆医科大学分子医学与肿瘤研究中心病理学教研室
- 作者简介：
- 基金信息：
- DOI：
  CLC： R737.11
- Published：2009，
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[1]杨春蓉,张徽,黄伟.肾恶性血管平滑肌脂肪瘤1例报告及文献复习[J].重庆医科大学学报,2009,34(12):1767-1770.

YANG Chun-rong, et al. Malignant renal angiomyolipoma a case report and literature review. [J]. Journal of Chongqing Medical University 34(12):1767-1770(2009)
[1]杨春蓉,张徽,黄伟.肾恶性血管平滑肌脂肪瘤1例报告及文献复习[J].重庆医科大学学报,2009,34(12):1767-1770. DOI：

YANG Chun-rong, et al. Malignant renal angiomyolipoma a case report and literature review. [J]. Journal of Chongqing Medical University 34(12):1767-1770(2009) DOI：

摘要

目的:探讨肾恶性血管平滑肌脂肪瘤（Malignant renal angiomyolipoma

MRAML）的临床病理特点

以提高对该病的认识。方法:分析本院病理科室收集的肾恶性血管平滑肌脂肪瘤标本

进行HE染色

光镜观察

免疫组化（S-P法）染色

结合临床诊治资料并复习文献。结果:肿瘤组织学形态示上皮样细胞、平滑肌样细胞以不同比例出现

可见厚壁血管

核分裂象明显

并可见病理性核分裂象及灶性坏死区域。免疫组化:上皮样及平滑肌样细胞都特征性表达黑色素特异性标识（4MB-45）、上皮膜抗原（Epithelial membrane antigen

EMA）、平滑肌标识（Actin）等。结论:B超、CT、MRI是诊断肾恶性血管平滑肌脂肪瘤的重要检查方法

家族史和详细的体格检查能够给我们提供重要的诊断线索

组织病理学特点结合免疫组化标记有助于该瘤的确诊。

Abstract

Objective:To investigate the clinicopathological features of malignant renal angiomyolipoma

to raise awareness of the disease.Methods:The malignant renal angiomyolipoma specimens collected by the pathology departments of the First Affiliated Hospital of Chongqing Medical University were analyzed.The specimens were under HE staining

light microscopy observation and immunohis tochemistry(SP method) staining.The information of clinical diagnosis and treatment were reviewed.Results:The characteristic histological patterns of the tumor was that epithelial cells

smooth muscle cells and fat cells appears in different proportion

thick-walled blood vessels could be seen

the mitosis was obvious

especially the pathological ones.Immunohistochemistry showed that epithelioid and smooth muscle cells characteristictly expresse HMB-45、EMA、Actin

and so on.Conclusion:B-ultrasonagraphy

MRI is an important methods in the diagnosis of malignant renal angiomyolipoma

detailed family history and physical examination to be able to provide us with important clues to the diagnosis and pathological characteristics combined with immunohistochemistry is important in the final confirmation of the tumor.

关键词

肾恶性血管平滑肌脂肪瘤免疫组化上皮样细胞

Keywords

Malignant renal angiomyolipomaimmunohistochemistryEpithelial-like cells

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