Effects of pioglitazone on carotid intima-media thickness in newly diagnosed type 2 diabetic patients

HE Yun; et al

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Effects of pioglitazone on carotid intima-media thickness in newly diagnosed type 2 diabetic patients

更新时间：2024-01-17

- Effects of pioglitazone on carotid intima-media thickness in newly diagnosed type 2 diabetic patients
- Journal of Chongqing Medical University Vol. 34, Issue 8, Pages: 1036-1038(2009)
- 作者机构：
  
  重庆市第五人民医院内分泌科
- 作者简介：
- 基金信息：
- DOI：
  CLC： R587.1
- Published：2009，
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[1]何云,王午喜,李茜,顾峻菱,朱爱东.吡格列酮对初诊2型糖尿病患者颈动脉内膜中层厚度的影响[J].重庆医科大学学报,2009,34(08):1036-1038.

HE Yun, et al. Effects of pioglitazone on carotid intima-media thickness in newly diagnosed type 2 diabetic patients. [J]. Journal of Chongqing Medical University 34(8):1036-1038(2009)
[1]何云,王午喜,李茜,顾峻菱,朱爱东.吡格列酮对初诊2型糖尿病患者颈动脉内膜中层厚度的影响[J].重庆医科大学学报,2009,34(08):1036-1038. DOI：

HE Yun, et al. Effects of pioglitazone on carotid intima-media thickness in newly diagnosed type 2 diabetic patients. [J]. Journal of Chongqing Medical University 34(8):1036-1038(2009) DOI：

摘要

目的:探讨吡格列酮对初诊2型糖尿病患者颈动脉内膜中层厚度（Carotid intima-media thickness

CIMT）的影响

分析其抑制动脉粥样硬化的可能机理。方法:62例初诊2型糖尿病患者随机分成吡格列酮治疗组（31例）与对照组（31例）

治疗前后检测CIMT及相关生化指标。结果:吡格列酮治疗组治疗后

CIMT值显著下降（P<0.01）

同时空腹血糖（FPG）、糖化血红蛋白（HbA1c）、空腹胰岛素（FINS）、胰岛素抵抗指数（HOMA-IR）、血清hsCRP显著下降（P<0.01）。而对照组除FPG和HbA1c下降具统计学意义（P<0.01）外

其他各项指标无明显变化（P>0.05）。结论:吡格列酮可能通过降低胰岛素抵抗及抗炎作用而显著降低初诊2型糖尿病患者CIMT水平

抑制糖尿病患者早期动脉粥样硬化的发生和发展。

Abstract

Objective:To investigate the change of carotid intima-media thickness(CIMT) in newly diagnosed patients with type 2 diabetic in response to pioglitazone and to analyse a possible mechanism of anti-atherosclerosis effects of pioglitazone.Method:Sixty-two newly diagnosed type 2 diabetic patients were randomly enrolled into treatment group with pioglitazone and control group.The CIMT and some relative biochemical indicators were measured.Results:After treatment with pioglitazone

the CIMT

fasting plasma glucose(FPG)

hemoglobin A1c(HbA1c)

fasting insulin(FINS)

high sensitive C reactive protein(hsCRP) and insulin resistance index(HOMA-IR) decreased significantly(P<0.01).Most data had no marked changes in the control group(P>0.05) but that the concentration of FPG and HbA1c were markedly lower than those before management(P<0.01).Conclusion:Pioglitazone slowed progression of CIMT in the newly diagnosed type 2 diabetic patients.Pioglitazone maybe delay the occurrence and development of atherosclerosis via the decreased insulin resistance and anti-inflammation actions.

关键词

吡格列酮2型糖尿病颈动脉内膜中层厚度噻唑烷二酮类药物动脉粥样硬化

Keywords

pioglitazoneType 2 diabetes diseaseCarotid intima-media thicknessThiazolidinedionesatherosclerosis

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