The expression and clinical significance of CD24 in human gastric carcinoma

JIAN Tao; et al

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The expression and clinical significance of CD24 in human gastric carcinoma

更新时间：2024-01-17

- The expression and clinical significance of CD24 in human gastric carcinoma
- Journal of Chongqing Medical University Vol. 34, Issue 10, Pages: 1348-1350(2009)
- 作者机构：
  
  重庆医科大学附属第一医院普外科
- 作者简介：
- 基金信息：
- DOI：
  CLC： R735.2
- Published：2009，
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[1]鉴涛,代远斌,黄淑君.CD24蛋白在胃癌中的表达及临床意义[J].重庆医科大学学报,2009,34(10):1348-1350.

JIAN Tao, et al. The expression and clinical significance of CD24 in human gastric carcinoma. [J]. Journal of Chongqing Medical University 34(10):1348-1350(2009)
[1]鉴涛,代远斌,黄淑君.CD24蛋白在胃癌中的表达及临床意义[J].重庆医科大学学报,2009,34(10):1348-1350. DOI：

JIAN Tao, et al. The expression and clinical significance of CD24 in human gastric carcinoma. [J]. Journal of Chongqing Medical University 34(10):1348-1350(2009) DOI：

摘要

目的:探讨CD24蛋白表达与胃癌发生、发展、病理分级、临床分期及浸润程度和淋巴结转移的关系。方法:采用免疫组织化学SP法检测56例手术切除并经病理检查证实的胃癌标本CD24蛋白的表达

CD24蛋白表达量以阳性率表示。结果:在56例胃癌组织中

45例（80.36%）CD24蛋白表达阳性

明显的高于癌旁组织17例（30.36%）

差别有显著统计学意义（P<0.0001）

且随着肿瘤细胞浸润程度（χ2=21.121 9

P<0.000 1）、淋巴结转移数目的增多（χ2=26.033 3

P<0.000 1）及TNM分期（χ2=18.402 9

P=0.000 4）的升高

CD24蛋白表达阳性率随之增高

且各组间比较差异有统计学意义。而与胃癌的组织学分型无相关性（r=0.190 1

P<0.160 4）。结论:CD24蛋白表达与胃癌细胞浸润程度（r=0.501 4

P<0.000 1）、淋巴结转移的数目（r=0.665 1

P<0.000 1）及TNM分期（r=0.405 6

P=0.001 9）呈正相关。CD24蛋白在肿瘤的发生、发展中起重要作用

且有可能成为判断胃癌患者生存的预后指标。

Abstract

Objective:To investigate the relationship between the expression of CD24 protein and carcinogenesis

development

the grade

clinical stage

depth of invasion

lymphnode metastasis of gastric carcinoma.Methods:CD24 protein expression of 56 gastric carcinomas were analysed by SP immunohistochemistry.The expression of CD24 protein was shown by the positive cells rate.Results:The positive rate of CD24 protein expression in gastric carcinoma tissues was 80.36%

obviously higher than 30.36% in the normal gastric tissue.The higher the grade

the lymphnode metastasis and the clinical stage of tumor were

the higher the expression of CD24 protein.And the differences amony each groups were statistically significant.Conclusion:The expression of CD24 protein has positive correlation with depth of invasion

lymphnode metastasis and the TNM stage of gastric carcinoma.The expression of CD24 protein may play a significant role in the development of the gastric carcinoma and be a prognostic marker for disease-free survival in the gastric carcinoma.

关键词

CD24蛋白胃癌预后指标

Keywords

CD24 proteingastric carcinomaPrognostic marker

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