Active cytomegalovirus infection before renal transplantation and it’s affection on the patients

JIANG Qing; et al

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Active cytomegalovirus infection before renal transplantation and it’s affection on the patients

更新时间：2024-01-17

- Active cytomegalovirus infection before renal transplantation and it’s affection on the patients
- Journal of Chongqing Medical University Vol. 34, Issue 9, Pages: 1180-1183(2009)
- 作者机构：
  
  1. 重庆医科大学附属第二医院泌尿外科
  2. 第三军医大学第二附属医院泌尿外科
- 作者简介：
- 基金信息：
- DOI：
  CLC： R512.99;R699.2
- Published：2009，
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[1]姜庆,王平贤,张银甫.同种异体肾移植前活动性CMV感染及其影响[J].重庆医科大学学报,2009,34(09):1180-1183.

JIANG Qing, et al. Active cytomegalovirus infection before renal transplantation and it’s affection on the patients. [J]. Journal of Chongqing Medical University 34(9):1180-1183(2009)
[1]姜庆,王平贤,张银甫.同种异体肾移植前活动性CMV感染及其影响[J].重庆医科大学学报,2009,34(09):1180-1183. DOI：

JIANG Qing, et al. Active cytomegalovirus infection before renal transplantation and it’s affection on the patients. [J]. Journal of Chongqing Medical University 34(9):1180-1183(2009) DOI：

摘要

目的:明确肾移植患者术前活动性巨细胞病毒（Cytomegalovirus

CMV）感染的发生状况及其对术后CMV的影响。方法:2006年6月

008年11月期间

使用荧光素标记的抗CMV-pp65单克隆抗体

检测156例肾移植患者术前外周血CMV-pp65抗原血症;肾移植后每2

周检测1次CMV-pp65抗原血症

共为期6个月;分析术前CMV-pp65抗原血症状况对术后患者CMV-pp65抗原血症强度和CMV病发生率的影响;另于同期内检测32例健康成人CMV-pp65抗原血症作相关对照。结果:32例健康成人CMV-pp65抗原血症均为（-）;肾移植前有12.2%（19/156）的尿毒症患者CMV-pp65抗原血症为（+）;这类患者肾移植后发生高活动性CMV感染（即CMV-pp65抗原血症指数

100）和CMV病的发生率均明显高于移植前CMV-pp65抗原血症为（-）的患者。结论:肾移植前活动性CMV感染高达12.2%;术前活动性CMV感染是导致肾移植后发生高活动性CMV感染和CMV病的重要原因。

Abstract

Objective:To discover the matter of active Cytomegalovirus (CMV) infection before renal transplantation and its affection on the patients after transplantation. Methods:the numbers of pp65 positive cells in peripheral blood in 32 normal persons who were used as control and 156 uremia patients before renal transplantation were determined between June 1

2006 and November 30

2008. The variations of number of pp65 positive cells in peripheral blood in patients after renal transplantation were investgated. Results: In control group the number of pp65 positive cells in peripheral blood was 0/5×104 WBC. Before renal transplantation there was 12.2 percent of uremia patients whose pp65 positive cell counting was more than 0 cell /5×104 WBC.In this kind of patient the case number of serious active CMV infection(pp65 positive cell counting was more than 100 cells /5×104 WBC) and CMV disease after renal transplantation was more than others.The difference was significant. Conclusions: The findings suggest that active CMV infection before renal transplantation is an important sake that causes serious active CMV infection and even CMV disease after renal transplantation.

关键词

肾移植巨细胞病毒

Keywords

kidney transplantationCytomegalovirus

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