The effects of probucol on 8-hydroxy-deoxyguanosine expressing in the kidney of type 2 diabetic rats

XU Xin; et al

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The effects of probucol on 8-hydroxy-deoxyguanosine expressing in the kidney of type 2 diabetic rats

更新时间：2024-01-17

- The effects of probucol on 8-hydroxy-deoxyguanosine expressing in the kidney of type 2 diabetic rats
- Journal of Chongqing Medical University Vol. 34, Issue 10, Pages: 1358-1361(2009)
- 作者机构：
  
  重庆医科大学附属第二医院内分泌科
- 作者简介：
- 基金信息：
- DOI：
  CLC： R587.1
- Published：2009，
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[1]徐鑫,刘东方,周厚地,闫纪强,龙敏.8羟基脱氧鸟苷在2型糖尿病大鼠肾脏的表达及Probucol的影响[J].重庆医科大学学报,2009,34(10):1358-1361.

XU Xin, et al. The effects of probucol on 8-hydroxy-deoxyguanosine expressing in the kidney of type 2 diabetic rats. [J]. Journal of Chongqing Medical University 34(10):1358-1361(2009)
[1]徐鑫,刘东方,周厚地,闫纪强,龙敏.8羟基脱氧鸟苷在2型糖尿病大鼠肾脏的表达及Probucol的影响[J].重庆医科大学学报,2009,34(10):1358-1361. DOI：

XU Xin, et al. The effects of probucol on 8-hydroxy-deoxyguanosine expressing in the kidney of type 2 diabetic rats. [J]. Journal of Chongqing Medical University 34(10):1358-1361(2009) DOI：

摘要

目的:观察8-羟基脱氧鸟苷（8-hydroxy-deoxyguanosine

8-OHdG）在2型糖尿病（Diabetesmellitus

DM）模型大鼠肾脏的表达及普罗布考（Probucol）对它的影响。方法:将大鼠分为正常对照组（Normol rats

C）、DM组（Diabetic rats

D）、普罗布考治疗组（Diabetic rats treated with probucol

N）

比较各组大鼠肾组织中丙二醛（Malondialdehyde

MDA）含量、超氧化物岐化酶（Superoxide dismutase

SOD）活性

和8羟基脱氧鸟苷（8-OHdG）含量

同时观察血糖、血胰岛素、肾功能和肾脏形态变化。结果:与正常组比较

DM组血液中MDA含量明显上升（P<0.05）

SOD活性显著下降（P<0.05）

8-OHdG增多（P<0.05）

肾功能和肾脏形态受损

而普罗布考治疗组的上述表达较DM组明显改善。结论:8-OHdG在DM肾病（Diabeticnephropathy

DN）中的表达明显增加

而普罗布考可以通过抑制氧化应激反应对2型DM模型大鼠肾脏产生保护作用。

Abstract

Objective:To evaluate the expression of 8-hydroxyguanine(8-OHdG) in type 2 diabetic rats and the effect of Probucol on it.Methods:25 rats were divided into 3 groups of normal rats(C)

diabetic rats(D)

and diabetic rats treated with Probucol(N).Content of malonaldehyde(MDA) and activity of antioxidant enzymes including superoxid edismutase(SOD) and 8-OHdG in the renal tissue were compared among the groups.In addition

blood glucose

serum creatinine(Cr) and blood ureanitrogen(BUN)were mesured;the renal tissue were observed by light micros copy and electron microscopy.Results:Compared with normal group

the level of BUN

MDA and 8-OHdG in Probucol untreated group were significantly increased

but the activity of SOD were decreased notably.In addition

the renal pathologic changes in Probucol untreated group was also decreased

but improved in the treared group obviously.Conclusion:Oxidative stress takes key point in the development of diabetic nephropathy.The expression of 8-OHdG in type2 diabetic rats were increased.Andantioxidation may be the possible mechanism of the nephroprotective action of Probucol.

关键词

8-羟基脱氧鸟苷（8-OHdG）普罗布考糖尿病肾病氧化应激

Keywords

8-hydroxy-deoxyguanosine(8-OHdG)probucoldiabeticnephropathyOxidarivestress

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