The effect of hypoglycemic therapy on the plasma omentin-1 levels in non-obesity type 2 diabetes mellitus

YANG Hao; LUO Yong; LIU Wei-juan; GUO Lian; XU Wei

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The effect of hypoglycemic therapy on the plasma omentin-1 levels in non-obesity type 2 diabetes mellitus

更新时间：2024-01-17

- The effect of hypoglycemic therapy on the plasma omentin-1 levels in non-obesity type 2 diabetes mellitus
- Journal of Chongqing Medical University Vol. 36, Issue 10, Pages: 1245-1248(2011)
- 作者机构：
  
  重庆市三峡中心医院内分泌科
- 作者简介：
- 基金信息：
- DOI：
  CLC： R587.1
- Published：2011，
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[1]阳皓,罗涌,刘维娟,郭莲,徐伟.不同降糖治疗对非肥胖2型糖尿病患者血浆网膜素-1水平的影响[J].重庆医科大学学报,2011,36(10):1245-1248.

YANG Hao, LUO Yong, LIU Wei-juan, et al. The effect of hypoglycemic therapy on the plasma omentin-1 levels in non-obesity type 2 diabetes mellitus. [J]. Journal of Chongqing Medical University 36(10):1245-1248(2011)
[1]阳皓,罗涌,刘维娟,郭莲,徐伟.不同降糖治疗对非肥胖2型糖尿病患者血浆网膜素-1水平的影响[J].重庆医科大学学报,2011,36(10):1245-1248. DOI：

YANG Hao, LUO Yong, LIU Wei-juan, et al. The effect of hypoglycemic therapy on the plasma omentin-1 levels in non-obesity type 2 diabetes mellitus. [J]. Journal of Chongqing Medical University 36(10):1245-1248(2011) DOI：

摘要

目的:观测不同葡萄糖耐量的非肥胖人群血浆网膜素-1（Omentin-1）水平

研究吡格列酮和短期持续皮下胰岛素输注

又称胰岛素泵（Continuous subcutaneous insulin infusion

CSII）强化治疗对2型糖尿病患者血浆omentin-1水平的影响。方法:59例非肥胖的初发2型糖尿病（Type 2 diabetes mellitus

T2DM）患者据血糖水平分别接受吡格列酮治疗12周（P组

27例）和CSII强化治疗2周（CSII组

32例）;用酶免法测定血浆omentin-1水平及相关代谢指标。结果:非肥胖T2DM患者空腹血浆o-mentin-1水平降低

以CSII组降低更为显著[（26.13±6.20）vs（22.01±7.51）vs（17.58±8.81）μg/L

P<0.05]。吡格列酮和CSII强化治疗均能使血浆omentin-1水平升高（22.01±7.51 vs 24.45±7.31）μg/L

（17.58±8.81 vs 22.32±8.69）μg/L

均P<0.05。结论:吡格列酮和CSII强化治疗均能升高血浆omentin-1水平

且血浆omentin-1水平可能与T2DM严重程度（表现为HbA1c）和胰岛素抵抗（Insulin resistance

IR）（表现为HOMA-IR）有关。

Abstract

Objective:To observe the plasma omentin-1 levels in non-obesity subjects with different glucose tolerance

investigate the effects of pioglitazone and short-term continuous subcutaneous insulin infusion(CSII) on plasma omentin-1 levels in patients with new-onset type 2 diabetes mellitus.Methods:59 patients with new-onset T2DM were treated with pioglitazone for 12 weeks or CSII for 2 weeks

respectively.Plasma omentin-1 levels were measured by an ELISA kit.The association between plasma omentin-1 levels and metabolic parameters were analyzed.Results:Fasting plasma omentin-1 levels were reduced in T2DM than in NGT groups(26.13±6.20 vs 22.01±7.51 vs 17.58±8.81) μg/L

P<0.05.Both pioglitazone and CSII therapy significantly elevated omentin-1 levels(22.01±7.51 vs 24.45±7.31) μg/L

(17.58±8.81 vs 22.32±8.69) μg/L

P<0.05 accompany with a decrease in HOMA-IR.Conclusion:In non-obesity T2DM patients

plasma omentin-1 levels are decreased

but significantly reverse after pioglitazone and CSII treatment.Omentin-1 may be associated with the severity(indicated as HbA1c values) and insulin resistance(indicated as HOMA-IR values) in T2DM.

关键词

脂肪细胞因子网膜素-12型糖尿病胰岛素抵抗

Keywords

adipokineomentin-1type 2 diabetes mellitusinsulin resistance

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