Effect of high intensity focused ultrasound on the humoral immunity of children with malignant solid tumor

AO Yu1; WANG Shan1; ZHU Hui2; WANG Zhi-biao2; KONG Xiang-ru1; ZHANG Jun1

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Effect of high intensity focused ultrasound on the humoral immunity of children with malignant solid tumor

更新时间：2024-01-17

- Effect of high intensity focused ultrasound on the humoral immunity of children with malignant solid tumor
- Journal of Chongqing Medical University Vol. 36, Issue 10, Pages: 1262-1264(2011)
- 作者机构：
  
  1. 重庆医科大学附属儿童医院肿瘤外科
  2. 重庆医科大学医学超声工程研究所
- 作者简介：
- 基金信息：
- DOI：
  CLC： R730.5
- Published：2011，
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[1]敖玉,王珊,朱辉,王智彪,孔祥如,章均.高强度聚焦超声对20例恶性实体肿瘤患儿体液免疫的影响[J].重庆医科大学学报,2011,36(10):1262-1264.

AO Yu1, WANG Shan1, ZHU Hui2, et al. Effect of high intensity focused ultrasound on the humoral immunity of children with malignant solid tumor. [J]. Journal of Chongqing Medical University 36(10):1262-1264(2011)
[1]敖玉,王珊,朱辉,王智彪,孔祥如,章均.高强度聚焦超声对20例恶性实体肿瘤患儿体液免疫的影响[J].重庆医科大学学报,2011,36(10):1262-1264. DOI：

AO Yu1, WANG Shan1, ZHU Hui2, et al. Effect of high intensity focused ultrasound on the humoral immunity of children with malignant solid tumor. [J]. Journal of Chongqing Medical University 36(10):1262-1264(2011) DOI：

摘要

目的:观察高强度聚焦超声（High intensity focused ultrasound

HIFU）对恶性实体肿瘤患儿体液免疫的影响。方法:采用HIFU治疗系统治疗儿童恶性实体肿瘤20例。分别在治疗前和后1周、1月抽取患儿外周血

用速率散射比浊法检测IgG、IgA、IgM、C3及C4表达量的变化。结果:IgG与C3的表达量在HIFU治疗前和后1周、1月分别依次为（9.08±1.49、9.02±1.54、10.38±1.72）g/L与（1.15±0.27、1.12±0.22、1.33±0.23）g/L。与治疗前比较

HIFU后1月恶性实体肿瘤患儿外周血IgG和C3表达量显著增加（P=0.015和P=0.027）;HIFU后1周、1月患儿IgA、IgM和C4表达量均无统计学意义（P>0.05）。结论:HIFU治疗可能对儿童恶性实体肿瘤患儿体液免疫有增强作用。

Abstract

Objective:To investigate the changes of humoral immunity in children with malignant solid tumor treated by high intensity focused ultrasound(HIFU).Methods:HIFU system was used to treat 20 children with malignant solid tumor.The levels of humoral immunity related indexes including IgG

IgA

IgM

C3 and C4 were tested by rate nephelometry before HIFU treatment

and 7 days and 1 month after HIFU treatment.Results:There were significant differences in the values of IgG and C3 between before and 1 month after HIFU treatment(P=0.017;P=0.022).No significant differences in the values of IgA

IgM and C4 were observed between before and after the ablation(P>0.05).Conclusion:HIFU may improve the humoral immunity in children with malignant solid tumor.

关键词

高强度聚焦超声儿童实体肿瘤体液免疫

Keywords

high intensity focused ultrasoundchildrensolid tumorhumoral immunity

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