The significance of the tumor cell cultured and drug sensitivity test after esophagectomy chemotherapy

YU Ping; ZHANG Zhi

您当前的位置：

首页 >

文章列表页 >

The significance of the tumor cell cultured and drug sensitivity test after esophagectomy chemotherapy

更新时间：2024-01-17

- The significance of the tumor cell cultured and drug sensitivity test after esophagectomy chemotherapy
- Journal of Chongqing Medical University Vol. 36, Issue 11, Pages: 1394-1397(2011)
- 作者机构：
  
  重庆市肿瘤研究所胸外科
- 作者简介：
- 基金信息：
- DOI：
  CLC： R735.1
- Published：2011，
扫描看全文
[1]羽平,张智.体外肿瘤细胞培养及药敏试验对食管癌术后化疗的意义[J].重庆医科大学学报,2011,36(11):1394-1397.

YU Ping, ZHANG Zhi. The significance of the tumor cell cultured and drug sensitivity test after esophagectomy chemotherapy. [J]. Journal of Chongqing Medical University 36(11):1394-1397(2011)
[1]羽平,张智.体外肿瘤细胞培养及药敏试验对食管癌术后化疗的意义[J].重庆医科大学学报,2011,36(11):1394-1397. DOI：

YU Ping, ZHANG Zhi. The significance of the tumor cell cultured and drug sensitivity test after esophagectomy chemotherapy. [J]. Journal of Chongqing Medical University 36(11):1394-1397(2011) DOI：

摘要

目的:通过对食管癌术后体外肿瘤细胞培养以及对不同药物及化疗方案的敏感性进行比较

寻找各自有效的、合理的化疗方案

指导食管癌的术后化疗。为个体化治疗提供理论依据。方法:采用组织块培养-终点染色-计算机图像分析（Tissueculture end point staining computer image analysis

TECIA）法对94例食管癌组织标本进行体外培养

并用8种常见化疗药物进行药物敏感性试验

了解其对肿瘤的抑制率

并将结果进行比较。结果:试验药物对食管鳞癌的抑制率各不相同

以紫杉醇类最高

阿霉素最低;单药与联合化疗方案的抑制率比较有显著差异

联合药敏感性高于单药。结论:食管癌的术后化疗

应根据每个食管鳞癌患者肿瘤的药敏结果

尽量选择敏感药物及联合用药的化疗方案。

Abstract

Objective:To guide for searching an effective and reasonable individualized chemotherapy after esophagectomy by the tumor cell cultured and tumor drug sensitivity test.Methods:compared with the inhibitory rate of tumor drug sensitivity test of 94 cases with esophageal cancer

intervered with 8 chemotherapy drugs used commonly in clinic

was determined by TECIA method.Results:The inhibitory rate of 8 chemotherapy drugs are different

PTX obtain best therapy effect

and ADM’s effect is minimum

and the combined chemotherapy effect is obvious better than a sole chemotherapy.Conclusion:The tumor drug sensitivity test have important value to determine the postoperative chemotherapy

and the treatment should select most sensitive drugs and combined chemotherapy.

关键词

食管癌肿瘤药敏试验

Keywords

esophageal carcinomatumor drug sensitivity test

references

Views

170

下载量

CSCD

Alert me when the article has been cited

提交

Tools

Publicity Resources

Association of NUSAP1 with tumor cell proliferation and immune cell infiltration in esophageal carcinoma: database based research

Relationship between expression of cyclooxygenase-2 and proliferation and apoptosis in esophageal carcinoma

Comparison between DDP and CMNa in radiosensitivity enhancement for patients with intermediate and advanced esophageal carcinoma

Effects of 5-FU combined with nimesulide on the expression of VEGF in human esophageal carcinoma Eca-109 (EC109)cell line

Apoptosis of Eca-109 cells treated with antisense oligodeoxynucleotide targeting survivin and trichosanthin

Related Author

Sun Xue

Li Zhongcheng

Bai Chengyun

Li Wenjun

Liu Yang

王丕龙

et al

WANG Shunwen

Related Institution

Department of Thoracic Surgery，Affiliated Hospital of Qinghai University

Department of Gastroenterology, College of Clinical Medicine, Chongqing Medical University

重庆医科大学临床学院消化内科

Department of Oncology,the First Affiliated Hospotal,Chongqing Medical University

重庆市肿瘤医院放疗科

⁰