Objective:To investigate the expression of Nucleoporin 88(Nup88) protein in colorectal adenoma as well as the correlation with the clinical features.Methods:One hundred sixty-three colorectal adenoma specimens

43 carcinoma specimens and 23 normal colorectal tissue specimens were examined by immunohistochemistry using the strepatavidin-peroxidase method.Relationship between Nup88 and the clinical features of colorectal adenoma was then analyzed.Results:The positive rate of Nup88 protein expression in normal mucosa

adenoma and colorectal carcinoma was 0%

43.56% and 55.81% respectively and there was significant difference within them(P<0.01).Nup88 expression in severe dysplasia(60.71%) was notably increased compared to the weak and moderate(40%

P=0.044).Nup88 expression was also closely related to the location of colorectal adenoma.When the adenoma located in the left colon or the rectum

Nup88 expression was significantly higher than that in the right(P<0.017).Conclusion:Increased expression of Nup88 in colorectal adenoma indicated Nup88 maybe play a promotive role in the tumorgenesis and development of colorectal cancer.