Inhibition study of G31P,a chemokine receptor CXCR1/2 antagonist,in proliferation of human prostate cancer cells in vivo and in vitro

LIU Xin 1; DENG Guo-ying 1; YANG Shu-feng 1; LI Fang 2

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Inhibition study of G31P,a chemokine receptor CXCR1/2 antagonist,in proliferation of human prostate cancer cells in vivo and in vitro

更新时间：2024-01-17

- Inhibition study of G31P,a chemokine receptor CXCR1/2 antagonist,in proliferation of human prostate cancer cells in vivo and in vitro
- Journal of Chongqing Medical University Vol. 36, Issue 12, Pages: 1420-1422(2011)
- 作者机构：
  
  1. 大连医科大学基础医学院微生物学教研室
  2. 大连医科大学基础医学院免疫学教研室
- 作者简介：
- 基金信息：
- DOI：
  CLC： R737.25
- Published：2011，
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[1]刘欣,邓国英,杨淑凤,李芳.CXCR1/CXCR2受体拮抗剂(G31P)对人前列腺癌增殖的体内外实验研究[J].重庆医科大学学报,2011,36(12):1420-1422.

LIU Xin 1, DENG Guo-ying 1, YANG Shu-feng 1, et al. Inhibition study of G31P,a chemokine receptor CXCR1/2 antagonist,in proliferation of human prostate cancer cells in vivo and in vitro. [J]. Journal of Chongqing Medical University 36(12):1420-1422(2011)
[1]刘欣,邓国英,杨淑凤,李芳.CXCR1/CXCR2受体拮抗剂(G31P)对人前列腺癌增殖的体内外实验研究[J].重庆医科大学学报,2011,36(12):1420-1422. DOI：

LIU Xin 1, DENG Guo-ying 1, YANG Shu-feng 1, et al. Inhibition study of G31P,a chemokine receptor CXCR1/2 antagonist,in proliferation of human prostate cancer cells in vivo and in vitro. [J]. Journal of Chongqing Medical University 36(12):1420-1422(2011) DOI：

摘要

目的:探讨CXCR1/CXCR2受体拮抗剂-G31P对人前列腺癌细胞PC-3增殖的体内外抑制作用。方法:采用CCK-8法研究不同浓度G31P对PC-3细胞体外增殖的抑制作用。建立体内绿色荧光蛋白（Green fluorescent protein

GFP）标记人雄激素非依赖性前列腺癌细胞PC-3裸鼠原位移植瘤模型

观察G31P对裸鼠前列腺癌原位移植瘤的体积、重量的影响。结果:CCK-8结果显示100 ng/ml G31P与对照组相比分别作用1、3 d和5 d差异具有统计学意义（1 d P=0.007、3 d P=0.001、5 d P=0.028

均为P<0.05）。前列腺癌PC-3细胞裸鼠模型体内实验显示

与对照组（100μl N.S）相比

G31P处理组（0.5 mg/kg）从给药第18天起能显著抑制前列腺肿瘤的体积（P=0.026

P<0.05）;与对照组相比G31P处理组在抑制前列腺肿瘤重量方面有明显作用（P=0.027

P<0.05）。结论:G31P体内外实验均能抑制人雄激素非依赖性前列腺癌细胞系PC-3的增殖。

Abstract

Objective:To investigate the effect of G31P on the proliferation of the prostate cancer in vivo and in vitro.Methods:The inhibition effect of G31P on the proliferation of PC-3 cell was investigated by CCK-8 assay in vitro.The effect of G31P on the volume and weight of human prostate tumor of nude mice was observed by building orthotopic transplantation tumor model of human androgen-independent prostate cancer PC-3(GFP-labeled) in nude mice.Results:CCK-8 assay found statistically significant difference in inhibiting the proliferation of PC-3 cells between the 100 ng/ml G31P and control group for 1 day(P<0.01)

3 days(P≤0.01) and 5 days(P<0.05).G31P treatment after the 18th day of administration inhibited significantly the prostate tumor volume compared with control group(P<0.05)

and this inhibition was more obvious(P<0.01) after the 24th day of administration in nude mice in vivo.A significant difference was observed between G31P treatment group(P<0.05) and the control group in prostate tumor weight.Conclusion:G31P can inhibit the proliferation of the prostate cancer in vivo and in vitro.

关键词

G31P前列腺癌CXCR1CXCR2

Keywords

G31Pprostate cancerCXCR1CXCR2

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