Research progress of pathogenesis and treatment of diabetic nonhealing wounds

Qin Panyue

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Research progress of pathogenesis and treatment of diabetic nonhealing wounds

更新时间：2025-09-11

- Research progress of pathogenesis and treatment of diabetic nonhealing wounds
- Journal of Chongqing Medical University Vol. 47, Issue 6, Pages: 670-675(2022)
- 作者机构：
  
  云南中医药大学中药学院,昆明,650500
- 作者简介：
- 基金信息：
- DOI：
  CLC： R587.2
- Published：2022
- 稿件说明：
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Qin Panyue. Research progress of pathogenesis and treatment of diabetic nonhealing wounds[J]. Journal of chongqing medical university, 2022, 47(6): 670-675.
DOI：

Qin Panyue. Research progress of pathogenesis and treatment of diabetic nonhealing wounds[J]. Journal of chongqing medical university, 2022, 47(6): 670-675. DOI：

摘要

糖尿病创面难愈与糖代谢异常关系密切，是临床常见、治疗棘手的并发症。由于其发病机制复杂且未完全明确，临床尚缺乏安全、高效的治疗方法。本文从皮肤“微环境污染”、过度氧化应激、“隐形损伤”、肠道菌群失衡等角度阐述了该病的发病机制，综述了细胞因子、高压氧、新材料、新药物应用等治疗研究进展，以期为该领域药物研发及临床治疗提供一定的理论基础及思路借鉴。

Abstract

Diabetic nonhealing wounds are closely related to glycometabolism

which is a common clinical and intractable complication. Due to its complicated pathogenesis

safe and efficient treatments are still in needs. This article described its relevant pathogenesis

including "microenvironmental contamination"

excessive oxidative stress

"hidden damage"

and intestinal microbiological disorder

etc. In addition

the research progress of cytokines

hyperbaric oxygen

new materials and application of new drug were reviewed

in order to provide a theoretical basis for research and development of drugs and clinical treatment in this field.

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Related Author

Lü Fajin

Zhang Ke

Tan Maolu

Yu Xiaoxia

Chen Zhongpei

Li Zhenhan

Zhou Yong

Peng Tingting

Related Institution

Department of Radiology，The First Affiliated Hospital of Chongqing Medical University

Department of Endocrinology，Chongqing Traditional Chinese Medicine Hospital

School of Basic Medical Sciences，Hubei University of Chinese Medicine

Department of Orthopedic Surgery，Shandong Provincial Hospital Affiliated to Shandong First Medical University

Department of Orthopaedics Surgery，West China Hospital

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