Objective：To explore the feasibility and efficacy of delicate management in the prevention of peripherally inserted central catheter （PICC） occlusion. Methods：A retrospective analysis was conducted in 971 cases admitted to our intensive care unit under－going PICC catheter from July 2014 to June 2017. Totally 530 patients who were admitted from July 2014 to December 2015 were defined as the control group，and 441 patients who were admitted during January 2016 to June 2017 were set as the observation group with application of delicacy management. The catheter occlusion rate，unplanned extraction events rates caused by occlusion and other catheter associated complications in two groups were compared. Results：With the application of delicacy management，the completely PICC catheter occlusion rate（ ?字2=4.522，P=0.038），incompletely PICC catheter occlusion rate（ ?字2=5.897，P=0.020），unplanned extrac－tion rate caused by occlusion（ ?字2=13.749，P=0.000） and catheter associated complications were significantly reduced（ ?字2=6.869，P=0.011）. Conclusion：Delicacy management can effectively prevent catheter occlusion and other catheter associated complications，thus prolongs the catheter indwelling time.