Objective：To explore risk factors for the ureteral stones leading to the development of patients with urosepsis as severe sepsis or septic shock. Methods：The clinical data of patients with ureteral calculi associated with urosepsis admitted to our hospital from January 2016 to December 2017 were retrospectively collected. According to the progress of severe sepsis or septic shock，the patients were divided into the case group and the control group. Univariate analysis was performed on the influencing factors of gender，age，body mass index（BMI），diabetes mellitus，history of previous stone surgery，stone site，stone size，degree of hydronephrosis，pe－ripheral white blood cell count，platelet count，serum albumin levels，creatinine，C-reactive protein（CRP），procalcitonin（PCT），urine culture and blood culture，and logistic regression analysis was performed on significant correlation risk factors. Results：Univariate analysis showed that the difference of gender，age，diabetes mellitus，peripheral blood leukocyte count，platelet count，serum creatinine，CRP，PCT were statistically significant（P<0.05）；the difference of BMI，the history of previous stone surgery，stone size，stones site，degree of hydronephrosis，serum albumin，urine culture，blood culture was not statistically significant（P>0.05）. Multivariate analysis showed that the most relevant factors associated with progression of urosepsis to severe sepsis/septic shock were age，peripheral white blood cell count，platelet count，and CRP. Conclusion：Age，peripheral blood leukocyte count，platelet count and CRP are the risk factors for the progression of ureteral calculi-causing sepsis to severe sepsis or septic shock and should be actively managed in these patients.