Regulation of TGF-β and BMPs signal pathways on abnormal proliferation in pulmonary artery smooth muscle cells

Ren Zhouxin; Li Jiansheng; Yu Haibin; Mei Xiaofeng; Liu Xuefang; Shen Junling

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Regulation of TGF-β and BMPs signal pathways on abnormal proliferation in pulmonary artery smooth muscle cells

更新时间：2023-12-22

- Regulation of TGF-β and BMPs signal pathways on abnormal proliferation in pulmonary artery smooth muscle cells
- Journal of Chongqing Medical University Vol. 43, Issue 3, Pages: 307(2018)
- 作者机构：
  
  1. 河南中医药大学呼吸疾病诊疗与新药研发河南省协同创新中心,郑州,450046
  2. 河南中医药大学第一附属医院心脏中心,郑州,450000
- 作者简介：
- 基金信息：
- DOI：
  CLC：
- Published：2018，
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Ren Zhouxin, Li Jiansheng, Yu Haibin, et al. Regulation of TGF-β and BMPs signal pathways on abnormal proliferation in pulmonary artery smooth muscle cells. [J]. Journal of Chongqing Medical University 43(3):307(2018)
DOI：

Ren Zhouxin, Li Jiansheng, Yu Haibin, et al. Regulation of TGF-β and BMPs signal pathways on abnormal proliferation in pulmonary artery smooth muscle cells. [J]. Journal of Chongqing Medical University 43(3):307(2018) DOI：

摘要

转化生长因子-β（transforming growth factor-β，TGF-β）超家族由多种细胞因子组成，主要的配体分为TGF-β和骨形成蛋白（bone morphogenetic protein，BMPs）两类。近年来发现，TGF-β和BMPs刺激调节肺血管平滑肌的增殖，相互之间存在拮抗，表现为Smads依赖和Smads不依赖2种方式；个体基因的变异可能导致TGF-β和BMPs对肺血管平滑肌细胞增殖产生不同甚至相反的效应。本文就转化生长因子-β及骨形成蛋白通路调节肺动脉血管平滑肌细胞异常增殖进行综述。

Abstract

The transforming growth factor-β（TGF-β） superfamily is composed of many cytokines，mainly including of TGF-βs and bone morphogenetic proteins（BMPs）. Recently，antagonism effect between TGF-βs and BMPs on proliferation in pulmonary artery smooth muscle cells is showed. Furthermore，individual genes variation might cause to different，even opposite effects of TGF-βs or BMPs on the proliferation. This article reviewed the regulation of TGF-β and BMPs signal pathways on abnormal proliferation in pul－monary artery smooth muscle cells.

关键词

肺动脉高压转化生长因子-β骨形成蛋白平滑肌细胞增殖

Keywords

pulmonary artery hypertensiontransforming growth factor-βbone morphogenetic proteinproliferation of pulmonary artery smooth muscle cells

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