Objective：To investigate the relationship between serum Zinc-α2-glycoproteins（ZAG） level and serum lipids in type 2 diabetes mellitus（T2DM）. Methods：Ninety newly diagnosed T2DM patients and eighty-seven healthy people were enrolled in the study. General clinical indices were recorded and fasting serum samples were collected from all subjects，serum lipids levels were mea－sured by enzymatic methods. Serum ZAG level was measured by ELISA. The relationship between ZAG and serum lipids were ana－lyzed by Pearson correlation analysis and multiple stepwise regression analysis. Results：The level of serum ZAG in patients with T2DM was lower than that of control group[（59.69±12.97） vs. （36.07±12.15） mg/L，P=0.000]，the level of fasting serum ZAG was lower in both non overweight T2DM group and overweight group[（60.95±13.05） vs. （38.93±10.59） mg/L，P=0.000；（56.36±12.42） vs. （33.78±12.92） mg/L，P=0.000]. The fasting serum ZAG level was correlated with HDL-C（r=0.345，P=0.001），BMI（r=-0.330，P=0.002），HOMA-IR（r=-0.290，P=0.006） in T2DM group，and serum ZAG levelin HDL-C≥1.04 group were higher than that of HDL-C＜1.04 group by hierarchical analysis with the cut-off value of HDL-C=1.04 mmol/L[（38.01±12.62） vs. （30.75±9.00） mg/L，P=0.011]；Whereas the fasting serum ZAG level was positively correlated with TC in control group（r=0.292，P=0.006），the serum ZAG levelin the TC≥5.18 group was higher than that of TC<5.18 group by hierarchical analysis with the cut-off value of TC=5.18 mmol/L[（63.36±12.03） vs. （56.97±13.09） mg/L，P=0.022]. Conclusion：The adipocyte factor ZAG may be correlated with the process of lipid metabolism disorder in T2DM，serum ZAG may play a beneficial role in promoting homeostasis of lipid metabolism.