Research progress of myocardial cation channels and myocardial ischemia reperfusion injury

Cheng Quanyi; Zhang Shizhong

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Research progress of myocardial cation channels and myocardial ischemia reperfusion injury

更新时间：2023-12-22

- Research progress of myocardial cation channels and myocardial ischemia reperfusion injury
- Journal of Chongqing Medical University Vol. 43, Issue 8, Pages: 1007(2018)
- 作者机构：
  
  三峡大学医学院生理与病理生理学教研室,宜昌,443002
- 作者简介：
- 基金信息：
- DOI：
  CLC：
- Published：2018，
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Cheng Quanyi, Zhang Shizhong. Research progress of myocardial cation channels and myocardial ischemia reperfusion injury. [J]. Journal of Chongqing Medical University 43(8):1007(2018)
DOI：

Cheng Quanyi, Zhang Shizhong. Research progress of myocardial cation channels and myocardial ischemia reperfusion injury. [J]. Journal of Chongqing Medical University 43(8):1007(2018) DOI：

摘要

心肌缺血再灌注损伤（myocardial ischemia-reperfusion injury，MIRI）是缺血心肌在恢复血流后常见的并发症。大量研究表明，分布于心肌细胞膜和相关细胞器的一些阳离子通道参与MIRI的相关病理生理过程：早期研究发现主要有Na+、K+和Ca2+ 离子通道参与MIRI过程，而近期最新发现瞬时受体电位（transient receptor potential，TRP）也参与MIRI过程，并可能成为新的MIRI药物干预靶点。本文拟对目前与MIRI密切相关的心肌细胞上Na+、K+和Ca2+及TRP等阳离子通道在MIRI病理生理中的作用作一综述。

Abstract

Myocardial ischemia-reperfusion injury（MIRI） is a common complication of ischemic myocardium after restoring blood flow. A large number of studies have shown that some of the cationic channels distributed in the myocardial cell membrane and related organelles are involved in the related pathophysiological processes of MIRI. Early studies have found that Na+，K+ and Ca2+ channels are involved in the MIRI process. Recent studies find that transient receptor potential（TRP） is also involved in MIRI and may be the new interfering target of medicine treatment. This paper aims to review the roles of the myocardial cation channels such as Na+，K+，Ca2+ and TRP in MIRI.

关键词

Na+离子通道K+离子通道Ca2+离子通道TRP通道心肌缺血再灌注损伤

Keywords

Na+ channelK+ channelCa2+ channeltransient receptor potential channelsmyocardial ischemia-reperfusion injury

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