Objective：To monitor the rules and characteristics of arrhythmia induced by aerosol inhalation of ventolin combined with ipratropium bromide，and to promote clinical rational drug use. Methods：A prospective study was conducted to observe the changes of heart rate before and after inhalation of ventolin combined with ipratropium bromide in 56 patients in Depart－ment of Respiratory Medicine of a three grade hospital. Results：Arrhythmia occurred in 7 cases（12.50%）. The occurrence of arrhythmia was not correlated with age and sex. Most arrhythmia occurs in 8 min after the start of atomization and 71.43% of the pa－tients with arrhythmia had abnormal ECG. Conclusion：In order to strengthen the safety of clinical medication，physicians and nurses should be aware of the adverse effects of inhalation of ventolin combined with ipratropium bromide on cardiac arrhythmias. And health care workers should be aware of rational use of drugs according to the patients’ condition. Observation of combined atomization should be strengthened to reduce and avoid the occurrence of arrhythmia.