There is an interaction between the interleukin-6（IL-6） and estrogen signaling pathways，and more importantly，the inter－action between these two signaling pathways plays an important in the development and progression of related diseases. Studies have shown that estrogen receptor can affect the development and severity of many diseases including breast cancer by regulating the ex－pression of the IL-6/STAT3 pathway；on the other hand，mutations of the estrogen and IL-6 genes are closely associated with various diseases. The interaction between the IL-6 and estrogen signaling pathways is of great significance in disease treatment，and treatment regimens based on these two signaling pathways bring hope to patients who have resistance to single-signal pathway therapy and hormone-related side effects and has a significant clinical value. This article reviews the influence of the interaction between the IL-6 and estrogen pathways on a variety of diseases，in order to provide new ideas for the treatment of diseases.