Objective：To investigate the application value of “one-stop” scanning combined CT angiography（CTA） for coronary and head-neck arteries and aorta with wide detector CT. Methods：Images of 80 patients who underwent CTA scans were analyzed. These patients were divided into 2 groups：Group A（n=40） and Group B（n=40）. Separate contrast injection protocol for aortic CTA with suspected aorta dissection and combined head-neck and coronary CTA for suspected cardiovascular disease were carried out on Group A. One-stop scan for combined coronary，head-neck and aortic CTA scans were carried out on Group B. Subjective evaluation and objective evaluation were performed for both two groups. Image quality，contrast dose，radiation dose，the total scan time between the two groups were compared. Results：There was no statistic difference in age，gender，heart rate，BMI and radiation dose between the two groups（P>0.05）. There was no statistic difference in subjective evaluation（P>0.05） and image quality in both groups met the requirement of diagnosis. There was no statistic difference in CT value and contrast nosie ratio（CNR） among M1 segment of the mid－dle cerebral artery，common carotid artery，vertebral artery V4 segment，RCA，LAD，LCX，aortic root，descending aorta，abdominal aor－ta and common iliac artery（P>0.05）. However，there were statistically significant differences in contrast dose and scan time between the two groups（P<0.05）. Compared with Group A ，the contrast dose and scan time reduced 45% and 52%，respectively，in Group B. Conclusion：Wide-detector CT can provide the “one-stop” examination for coronary，head-neck and aortic arteries with single contrast injection to obtain equivalent image quality as the conventional dual-injection protocol with reduced contrast dose and examina－tion time. It is useful for preoperative evaluation of patients with aortic dissection.