Objective：To investigate the role of long non-coding RNA LINC00152 in papillary thyroid carcinoma（PTC）. Methods：A total of 32 patients with PTC were enrolled. Tumor tissue and adjacent normal tissue samples were collected during surgery，and qRT-PCR was used to measure the expression of LINC00152 in these samples. Knockdown of LINC00152 was performed to establish a PTC cell line with low expression of LINC00152，and Transwell migration and invasion experiments，cell cloning experiments，growth experiments，and wound healing assay were used to investigate the role of LINC00152 in the development and progression of PTC. Results：In 64 of all patients with PTC，the expression of LINC00152 in tumor tissue was higher than that in adjacent normal tissue（P<0.01）. In vitro cell experiments demonstrated that knockdown of LINC00152 reduced the growth，proliferation，invasion，and mi－gration abilities of PTC cells. Conclusion：Long non-coding RNA-LINC00152 has high expression in PTC and reduction in LINC00152 can significantly reduce the malignant ability of PTC cells.