patients with intrauterine adhesions

Zheng Jing; Wang Jishu; Yuan Rui

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patients with intrauterine adhesions

更新时间：2023-12-22

- patients with intrauterine adhesions
- Journal of Chongqing Medical University Vol. 44, Issue 8, Pages: 1054(2019)
- 作者机构：
  
  1. 重庆医科大学附属第一医院妇产科,重庆,400016
  2. 重庆市渝北区妇幼保健院妇科,重庆,401120
- 作者简介：
- 基金信息：
- DOI：
  CLC：
- Published：2019，
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Zheng Jing, Wang Jishu, Yuan Rui. patients with intrauterine adhesions. [J]. Journal of Chongqing Medical University 44(8):1054(2019)
DOI：

Zheng Jing, Wang Jishu, Yuan Rui. patients with intrauterine adhesions. [J]. Journal of Chongqing Medical University 44(8):1054(2019) DOI：

摘要

目的：探究锌指蛋白Snail与转录调节因子核因子－κＢ（nuclear factor－κB，NF-κB）在宫腔粘连（intrauterine adhesions，I－UAs）患者子宫内膜中的表达。方法：选择34例宫腔粘连患者作为试验组（IUAs），非宫腔粘连患者19例作为对照组（control），在宫腔镜直视下取子宫内膜组织。采用实时荧光定量PCR、免疫组织化学和Western blot分别检测 NF-κB、Snail、E-cadherin、Vimentin mRNA水平和蛋白水平的表达。结果：与对照组相比较，宫腔粘连患者子宫内膜组织中NF-κB（2.478±0.279 vs. 1.459±0.323，P=0.013）、Snail（2.801±0.502 vs. 1.218±0.313，P=0.005）、 Vimentin（3.581±0.650 vs. 1.756±0.260，P=0.006）的表达明显升高，E-cadherin（1.324±0.617 vs. 2.784±0.647，P=0.023）表达明显降低。结论：NF-κB和Snail可能参与了宫腔粘连的发生发展。

Abstract

Objective：To examine the expression of zinc finger protein Snail and nuclear factor kappa B（NF-κB） in the endometrium of patients with intrauterine adhesions（IUAs）. Methods：Endometrial tissues were collected by hysteroscopy from 34 IUA patients（IUA group） and 19 non-IUA patients（control group）. The mRNA and protein expression levels of NF-κB，Snail，E-cadherin，and Vimentin were determined using real-time quantitative PCR，immunohistochemistry，and Western blot. Results：The IUA group had significantly increased expression of NF-κB（2.478±0.279 vs. 1.459±0.323，P=0.013），Snail（2.801±0.502 vs. 1.218±0.313，P= 0.005），and Vimentin（3.581±0.650 vs. 1.756±0.260，P=0.006），but significantly reduced expression of E-cadherin（1.324±0.617 vs. 2.784±0.647，P=0.023），as compared with the control group. Conclusion：NF-κB and Snail may be involved in the development and progression of IUA.

关键词

宫腔粘连核因子-κBsnail

Keywords

intrauterine adhesionnuclear factor-κBsnail

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Related Institution

Department of Traditional Chinese Medicine，Chongqing General Hospital

Department of Traditional Chinese Medicine Rehabilitation，The Affiliated Rehabilitation Hospital of Chongqing Medical University

Key Laboratory of Traditional Chinese Medicine for Prevention and Cure of Metabolic Diseases，College of Traditional Chinese Medicine of Chongqing Medical University

Department of Obstetrics and Gynecology,University-Town Hospital of Chongqing Medical University

Department of Gynaecology and Obstetrics,Chongqing Health Center for Women and Children

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