Objective：To investigate the differences in coronary artery branch diameter，distribution type，and aortic sinus diameter on coronary CT angiography（CCTA） between the healthy Han and Uygur adults in Southern Xinjiang，China and their correlation. Methods：A retrospective analysis was performed for the CCTA data of the healthy Han and Uygur adults who underwent physical ex－amination in The First People’s Hospital of Kashgar from January 2016 to January 2017. A total of 300 healthy Uygur adults with normal coronary artery（173 male and 127 female adults aged 40-60 years，with a mean age of 50.03±7.82 years） and 300 healthy Han adults with normal coronary artery（193 male and 107 female adults aged 40-60 years，with a mean age of 51.36±8.40 years） were randomly selected. Curved planar reformation，maximum intensity projection，and volume rendering reconstruction of the coronary artery were performed，and the American Heart Association 15-segment method was used to measure the differences in the diameter of the right coronary artery，the left anterior descending artery，the circumflex coronary artery，and the proximal and middle segments of the obtuse marginal branch，aortic sinus diameter，and the distribution of coronary artery between the Han and Uygur population. Results：Compared with the Han group，the Uygur group had significantly larger diameters of the left anterior descending artery，the circumflex coronary artery，and the proximal and middle segments of the obtuse marginal branch（P<0.05）. Among the 300 healthy Han adults，24（8.0%） were left dominant，246（82.0%） were right dominant，and 30 （10.0%） were balanced. Among the 300 healthy Uygur adults，104（34.66%） were left dominant，184（61.33%） were right dominant，and 12 （4.0%） were balanced；there was a significant difference in the distribution of dominant coronary arteries between the two groups（P<0.05）. There were no significant differences be－tween the two groups in diameter of the right coronary artery and aortic sinus diameter（P>0.05）. Conclusion：There are differences in coronary artery diameter and distribution type between the healthy Uygur and Han adults in Southern Xinjiang.