Preparation and quality evaluation of Dextromethorphan chewing gum drug delivery system

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Preparation and quality evaluation of Dextromethorphan chewing gum drug delivery system

更新时间：2023-12-18

- Preparation and quality evaluation of Dextromethorphan chewing gum drug delivery system
- Journal of Chongqing Medical University Vol. 37, Issue 5, Pages: 442-444(2012)
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- Published：2012，
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Preparation and quality evaluation of Dextromethorphan chewing gum drug delivery system. [J]. Journal of Chongqing Medical University 37(5):442-444(2012)
DOI：

Preparation and quality evaluation of Dextromethorphan chewing gum drug delivery system. [J]. Journal of Chongqing Medical University 37(5):442-444(2012) DOI：

摘要

目的：筛选出最佳的右美沙芬(Dextromethorphan，DM)咀嚼胶制剂处方，制备制剂并进行质量评价。方法：采用正交设计优化咀嚼胶制剂，压片法制备DM咀嚼胶制剂。结果：正交设计优化后的DM咀嚼胶制剂最佳处方为：胶基、阿斯巴甜、薄荷脑和香精的用量分别为90%、3%、0.5%和0.2%。结论：DM咀嚼胶制剂制备工艺合理，质量符合要求。

Abstract

Objective:To select the best prescription for Dextromethorphan (DM) chewing gum preparation and to evaluate its quality. Methods: The DM chewing gum preparation was prepared by tablet press method; the formulation was optimized by orthogonal experiments.Results: The best prescription based on the results of orthogonal experiments was that the proportion of gum base

aspartame

menthol and essence was 90%

0.5% and 0.2%

respectively. Conclusion: DM chewing gum preparation can be successfully formulated and its quality can be guaranteed.

关键词

右美沙芬咀嚼胶给药系统制备工艺质量评价

Keywords

Dextromethorphanchewing gum drug delivery systempreparation methodquality evaluation

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Metabolism method of dextromethorphan in vitro

Related Author

ZHANG Li-li

刘颖菊

袁佩

杨贵忠

周岐新

廖飞

Related Institution

Department of Pharmacology,College of Pharmacy,Chongqing Medical University

重庆医科大学药学院医药研究所

重庆市生物化学与分子药理重点实验室重庆市生物化学与分子药理重点实验室

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