Expression of Survivin gene in hepatic regeneration tissue of rat after partial hepatectomy

JIN Yuji; WANG Dexin; CHEN Xiaoli; ZHANG Haifeng; YE Susu; HOU Qingshun

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Expression of Survivin gene in hepatic regeneration tissue of rat after partial hepatectomy

更新时间：2023-12-18

- Expression of Survivin gene in hepatic regeneration tissue of rat after partial hepatectomy
- Journal of Chongqing Medical University Vol. 37, Issue 1, Pages: 59-62(2012)
- 作者机构：
  
  山东省青岛市传染病医院肝病科,青岛,266033
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- Published：2012，
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JIN Yuji, WANG Dexin, CHEN Xiaoli, et al. Expression of Survivin gene in hepatic regeneration tissue of rat after partial hepatectomy. [J]. Journal of Chongqing Medical University 37(1):59-62(2012)
DOI：

JIN Yuji, WANG Dexin, CHEN Xiaoli, et al. Expression of Survivin gene in hepatic regeneration tissue of rat after partial hepatectomy. [J]. Journal of Chongqing Medical University 37(1):59-62(2012) DOI：

摘要

目的：探讨Survivin在大鼠肝部分切除（Partial hepatectomy，PH）后肝再生过程中的作用及其意义。方法：用70%肝部分切除方法，建立Wister大鼠肝再生模型，在肝再生不同时间点，采用免疫组化及Western blot方法，检测肝组织中Survivin和细胞周期相关蛋白CyclinD1的表达。结果：在肝切除术后12~72 h，Survivin蛋白表达量明显增高，且在48 h达到峰值，细胞周期相关蛋白CyclinD1在术后12、24、48、72 h均表达上调，与Survivin蛋白表达具有高度相关性。结论：Survivin蛋白的高表达与肝部分切除后肝再生过程密切相关。

Abstract

Objective：To investigate the effects and its significance of survivin gene in rat liver regeneration after partial hepatectomy. Methods：Wister rat liver regeneration model of 70% partial hepatectomy was established. The expressions of Survivin and cell cycle-related protein cyclinD1 were detected by immunohistochemistry in liver regeneration rat tissues at different time points. Results：The level of Survivin protein expression was significantly increased during 12~72 h after partial hepatectomy and reached its peak at 48 h after partial hepatectomy. The level of cyclinD1 was upregulated at 12，24，48 h，and 72 h after partial hepatectomy and highly correlated with survivin protein level. Conclusion：The high expression of Survivin protein is significantly correlated with the liver regeneration after partial hepatectomy.

关键词

SurvivincyclinD1肝切除肝再生

Keywords

SurvivincyclinD1hepatectomylive regeneration

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