Prognosis assessment on cervical intraepithelial neoplasia Ⅱ-Ⅲ with positive margins after LEEP by human papillomavirus genotyping

WU Jin; JIA Ying; TANG Liangdan

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Prognosis assessment on cervical intraepithelial neoplasia Ⅱ-Ⅲ with positive margins after LEEP by human papillomavirus genotyping

更新时间：2023-12-18

- Prognosis assessment on cervical intraepithelial neoplasia Ⅱ-Ⅲ with positive margins after LEEP by human papillomavirus genotyping
- Journal of Chongqing Medical University Vol. 37, Issue 7, Pages: 642-644(2012)
- 作者机构：
  
  重庆医科大学附属第一医院妇产科,重庆,400016
- 作者简介：
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- Published：2012，
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WU Jin, JIA Ying, TANG Liangdan. Prognosis assessment on cervical intraepithelial neoplasia Ⅱ-Ⅲ with positive margins after LEEP by human papillomavirus genotyping. [J]. Journal of Chongqing Medical University 37(7):642-644(2012)
DOI：

WU Jin, JIA Ying, TANG Liangdan. Prognosis assessment on cervical intraepithelial neoplasia Ⅱ-Ⅲ with positive margins after LEEP by human papillomavirus genotyping. [J]. Journal of Chongqing Medical University 37(7):642-644(2012) DOI：

摘要

目的：对宫颈上皮内瘤样病变（Cervical intraepithelial neoplasia，CIN）Ⅱ～Ⅲ行超频电刀环切术（Loop electrosurgical excision procedure，LEEP）术后切缘阳性患者定期随访，通过人乳头状瘤病毒（Human papillomavirus，HPV)分型检测进行预后评估，从而指导临床合理治疗；方法：回顾性分析702例CINⅡ～Ⅲ中行LEEP术后切缘阳性的患者65例（9.26%），检测其术前、术后6、12、18月及24月HPV分型、薄层液基细胞学涂片（ThinPrep cell test，TCT）及阴道镜情况；结果：切缘阳性患者复发率高于切缘阴性患者（P<0.05）；术前各HPV亚型、多重HPV感染以及切缘残留病灶级别与患者的复发率无相关性（P＞0.05）；但术后6月HPV持续感染与高复发率有密切相关性（P<0.05）；讨论：CINⅡ～Ⅲ LEEP术后切缘阳性患者定期行HPV分型，可有助于检测病灶复发。

Abstract

Objective：To assess the prognosis after loop electrosurgical excision procedure（LEEP） of cervical intraepithelial neopla－siaⅡ-Ⅲ（CINⅡ-Ⅲ） with positive margins by human papillomavirus（HPV） genotyping in order to guide clinical treatment. Meth－ods：Totally 65 cases （9.26%） were found positive margins in 702 cases of CINⅡ-Ⅲ after LEEP. ThinPrep cell test（TCT），colpo－scope and HPV genotype were performed preoperatively and at every 6 months after LEEP. Results：The recurrence rate of positive margins was higher than that of negative margins（P<0.05）. The recurrence was not correlated with HPV subtype，multiple HPV types and lesions grade in incision margins（P ＞0.05）. But the persistence HPV infection was associated with higher recurrence rates at 6 months after the operation（P<0.05）. Conclusion：HPV genotype may help to detect recurrences in CINⅡ-Ⅲ with positive margins after LEEP.

关键词

超频电刀环切术宫颈上皮内瘤样病变切缘阳性人乳头状瘤病毒

Keywords

loop electrosurgical excision procedurecervical intraepithelial neoplasiapositive marginshuman papillomavirus

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Related Institution

Department of Gynecology and Obstetrics,The First Affiliated Hospital of Chongqing Medical University

Department of Obstetrics and Gynecology,College of Clinical Medicine,Chongqing Medical University

(Outpatient Department of Gynecology,Chongqing Obstetric and Gynecology Hospital，Chongqing Special Department of Cervical Disease)

Department of Gynecology，the Fifth Affiliated Hospital，Guangxi Medical University

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