Objective：To explore a new preventing and treating method for diaper dermatitis in elderly patients. Methods：Totally 68 elderly patients with diaper dermatitis were included in the present study. Diaper dermatitis was caused by fecal and urine incontinence resulted from various factors. The patients were randomly divided into two groups（n=34）. The buttocks of all patients were thor－oughly cleaned with warm water and soft towels or wet wipes at the beginning of the study. In Sanyrene and Iodophors group（obser－vation group），0.5% Iodophor was evenly rubbed into the flushed skin outside-in，then was cleaned with normal saline after being dried，then Sanyrene was evenly sprayed into the flushed skin after being dired. In Sanyrene group（control group），Sanyrene was well sprayed into the flushed skin according to the methods above. The procedure was performed respectively in both groups three times a day and the efficacy and healing time were observed. Results：Significant differences were found in the curative rate and healing time between the two groups（P＜0.05）. Conclusion：Sanyrene combined with Iodophor is an effective method for preventing and treating diaper dermatitis in elderly patients.