Expression of Survivin and MMP-2 in breast carcinoma and their correlation

GONG Huilin; ZHANG Suoping; ZHANG Guanjun; DONG Weijiang

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Expression of Survivin and MMP-2 in breast carcinoma and their correlation

更新时间：2023-12-18

- Expression of Survivin and MMP-2 in breast carcinoma and their correlation
- Journal of Chongqing Medical University Vol. 37, Issue 2, Pages: 106-109(2012)
- 作者机构：
  
  1. 西安交通大学医学院第一附属医院病理科,西安,710061
  2. 陕西扶风县人民医院病理科,宝鸡,722200
  3. 西安交通大学医学院解剖学系,西安,710061
- 作者简介：
- 基金信息：
- DOI：
  CLC：
- Published：2012，
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GONG Huilin, ZHANG Suoping, ZHANG Guanjun, et al. Expression of Survivin and MMP-2 in breast carcinoma and their correlation. [J]. Journal of Chongqing Medical University 37(2):106-109(2012)
DOI：

GONG Huilin, ZHANG Suoping, ZHANG Guanjun, et al. Expression of Survivin and MMP-2 in breast carcinoma and their correlation. [J]. Journal of Chongqing Medical University 37(2):106-109(2012) DOI：

摘要

目的：通过检测Survivin和基质金属蛋白酶2（Matrix metalloproteinase 2，MMP-2）在乳腺癌组织中的表达，研究两者的相关性及其在乳腺癌发生发展中的意义。方法：用免疫组织化学S-P法检测114例乳腺癌中Survivin、MMP-2的表达，分析其相关性及二者与乳腺癌临床分期、病理组织学分级、腋窝淋巴结转移、5年生存率的关系。结果：Survivin、MMP-2在乳腺癌中的阳性表达率分别为71.05%和75.40%，显著高于两者在正常乳腺中的表达率，且二者表达呈正相关（P<0.05）；并均与乳腺癌临床分期、病理组织学分级、腋窝淋巴结转移、5年生存率密切相关（P<0.05）。结论：Survivin、MMP-2基因表达与乳腺癌的发生发展密切相关，联合检测有助于乳腺癌预后的判断。

Abstract

Objective：To discuss the relationship between and significance of the expressions of Survivin and MMP-2 in carcinogene－sis and progression of breast carcinoma through detection and investigation. Methods：The expressions of Survivin and MMP-2 in 114 cases breast carcinoma tissues were detected by immunohistochemistry SP method.The relationship between Survivin and MMP-2 was analyzed，and their correlations with clinical stage，tumor grade of differentiation，axillary lymph node metastasis，and 5-year disease-free survival were also studied. Results：The positive expression rates of Survivin and MMP-2 in breast carcinoma were 71.05% （81/114） and 75.40% （84/114），respectively，which were significantly higher than those in normal breast tissue.Survivin expression had a positive correlation with MMP-2.Both Survivin and MMP-2 were correlated with the clinical stage，pathology grade，axillary lymph nodes metastasis，and 5-year disease-free survival （P<0.05）. Conclusion：The expressions of Survivin and MMP-2 are significantly correlated with the occurrence and development of breast carcinoma. Detection of these two expressions may be valuable for evaluating the prognosis of breast carcinoma.

关键词

乳腺癌Survivin基质金属蛋白酶２

Keywords

breast carcinomaSurvivinmatrix metalloproteinase 2（MMP-2）

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