Spatiotemporal expression of S100A2 in peri-implantation mouse endometrium WANG Sheng1，LIU Zhenzhen1，TAN Yi1，ZHOU Lan2，TAN Dongmei1

WANG Sheng; LIU Zhenzhen; TAN Yi; ZHOU Lan; TAN Dongmei

您当前的位置：

首页 >

文章列表页 >

Spatiotemporal expression of S100A2 in peri-implantation mouse endometrium WANG Sheng1，LIU Zhenzhen1，TAN Yi1，ZHOU Lan2，TAN Dongmei1

更新时间：2023-12-18

- Spatiotemporal expression of S100A2 in peri-implantation mouse endometrium WANG Sheng1，LIU Zhenzhen1，TAN Yi1，ZHOU Lan2，TAN Dongmei1
- Journal of Chongqing Medical University Vol. 37, Issue 6, Pages: 507-510(2012)
- 作者机构：
  
  1. 重庆医科大学 1.实验动物中心
  2. 检验医学院,重庆,400016
- 作者简介：
- 基金信息：
- DOI：
  CLC：
- Published：2012，
扫描看全文
WANG Sheng, LIU Zhenzhen, TAN Yi, et al. Spatiotemporal expression of S100A2 in peri-implantation mouse endometrium WANG Sheng1，LIU Zhenzhen1，TAN Yi1，ZHOU Lan2，TAN Dongmei1. [J]. Journal of Chongqing Medical University 37(6):507-510(2012)
DOI：

WANG Sheng, LIU Zhenzhen, TAN Yi, et al. Spatiotemporal expression of S100A2 in peri-implantation mouse endometrium WANG Sheng1，LIU Zhenzhen1，TAN Yi1，ZHOU Lan2，TAN Dongmei1. [J]. Journal of Chongqing Medical University 37(6):507-510(2012) DOI：

摘要

目的：了解S100A2 mRNA及蛋白在围着床期小鼠子宫的表达情况，为阐明S100A2在胚胎着床过程中的作用积累实验依据。方法：应用荧光定量PCR（FQ-PCR）和免疫组化技术分别检测S100A2 mRNA和蛋白的表达情况。结果：①S100A2 mRNA在妊娠第1～6天子宫中均有表达，且表达量逐渐降低；同时，在第5天，着床点的含量明显低于非着床点。②S100A2蛋白主要表达于小鼠子宫内膜基质细胞的胞浆中，其表达量在第1、2天很丰富，第3、4、5天很低。③子宫内膜的腔上皮和腺上皮细胞未见S100A2表达。结论：在胚胎着床过程中，S100A2在小鼠子宫中的表达呈动态变化，提示可能参与了子宫内膜对滋养层细胞侵袭的调控。

Abstract

Objective：To identify the expression pattern of S100A2 mRNA and protein in peri-implantation endometrium in mice，and to accumulate experimental proof which S100A2 might play roles in embryo implantation. Methods：mRNA and protein expression of S100A2 were detected by fluorescence quantitative polymerase chain reaction（FQ-PCR） and immunohistochemistry. Results：① S100A2 mRNA was steadily expressed in the mouse uterus during d1-d6 of pregnancy，and its quantity gradually decreased day by day. On d5 of pregnancy，its expression level was lower in the implantation sites than that in inter-implantation sites. ②S100A2 pro－tein was localized in cytoplasm of mouse endometrial stromal cells，while its level dynamically changed:strongly positive on d1-d2，weakly positive on d3-d5. ③No expression was detected in endometrial luminal epithelial cells and gland cells. Conclusion：Dynamic expression of S100A2 in mouse uterus during embryo implantation shows that it might play roles in regulation of embryo invasion into the uterine endometrium.

关键词

S100A2子宫内膜胚胎着床

Keywords

S100A2endometriumembryo implantation

references

Views

1065

下载量

CSCD

Alert me when the article has been cited

提交

Tools

Publicity Resources

Expression of growth factor receptor bound 7 in the endometrium of early pregnant mouse

Expression rules and potential role of mmu-miR-106b in the endometrium of mouse during embryo implantation

Expression of Dicer in the endometrium of early pregnant mouse

Expressions of uPA,PAI-1,and TGF-β1 in the endometrium of patients with intrauterine adhesion and their correlation

Effect of Benzo(a)pyrene on embryo implantation in mice during early pregnancy

Related Author

TANG Jun

LI Rong

GENG Yanqing

ZHOU Yongjiang

CHEN Xuemei

HE Junlin

LIU Xueqing

YANG Dehui

Related Institution

Laboratory of Reproductive Biology，School of Public Health and Management，Chongqing Medical University

Teaching and Research Section of Reproductive Biology，School of Public Health and Management，Chongqing Medical University

Department of Obstetrics and Gynecology,University-Town Hospital of Chongqing Medical University

Teaching and Research Section of the Reproductive Biology,School of Public Health and Management,Chongqing Medical University

Department of Comprehensive Herbal Medicine,Traditional Chinese Medicine School,Chongqing Medical University

⁰